Progestin Permeation through Polymer Membranes IV: Mechanism of Steroid Permeation and Functional Group Contributions to Diffusion through Hydrogel Films
| Autor: | Suk‐Zu ‐Z Song, Jan Feijen, Gaylen M. Zentner, John R. Cardinal |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
chemistry.chemical_classification
Chemistry Ethylene glycol dimethacrylate Synthetic membrane Pharmaceutical Science Membranes Artificial (Hydroxyethyl)methacrylate Polymer Permeation Permeability Diffusion Partition coefficient Structure-Activity Relationship chemistry.chemical_compound Models Chemical Solubility Chemical engineering Polymer chemistry Bound water Steroids Polyhydroxyethyl Methacrylate |
| Zdroj: | Journal of Pharmaceutical Sciences. 68:970-975 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600680814 |
| Popis: | Hydrogel films were prepared from hydroxyethyl methacrylate, both with (Film II) and withouth (Film I) 5.25 mole% of ethylene glycol dimethacrylate. Permeation, diffusion, and partition coefficients for progesterone, testosterone, nandrolone, norethindrone, 17 alpha-hydroxyprogesterone, estradiol, and hydrocortisone were determined. A solute permeation model was proposed based on the separation of a domain (B) composed of "bulk-like" water and a doman (A) composed of polymer, interfacial water, and bound water present in the films. The separate contributions from the "pore" and "solution-diffusion" mechanisms to the total permeability were calculated from the model. Steroid permeabilities through Films I and II were analyzed in accordance with this model. Permeation of Film II occurred via the solution-diffusion mechanism. Permeation of Film I occurred predominately by the pore mechanism with a small contribution (approximate 20%) from the solution-diffusion mechanism. The latter contribution was dependent on the solubility of the solute within the A domains of the hydrogel film. Functional group contributions to permeation of Film II were ascribed to either steric or hydrogen bonding effects. |
| Databáze: | OpenAIRE |
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