Impact of the favorable prognosis of patients with lung cancer adjoining bullae
| Autor: | Masaki Matsuo, Fumihiro Tanaka, Shuichi Shinohara, Masakazu Sugaya, Kazuhiko Machida, Kazuo Kato, Takamitsu Onitsuka |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty Multivariate analysis business.industry Proportional hazards model Hazard ratio Favorable prognosis medicine.disease Gastroenterology Confidence interval 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Internal medicine medicine Original Article Lung cancer business Pathological Survival analysis |
| Zdroj: | Journal of Thoracic Disease. 10:3289-3297 |
| ISSN: | 2077-6624 2072-1439 |
| DOI: | 10.21037/jtd.2018.05.125 |
| Popis: | Background: Lung cancer adjoining bullae (LC-AB) is an uncommon manifestation. The clinical characteristics and prognosis of LC-AB remain unclear. The aim of this study is to investigate the clinical features and overall survival (OS) of patients with LC-AB following lung resection compared to non-LC-AB group. Methods: We retrospectively investigated 291 consecutive patients with lung cancer who underwent curative resection in a single institution between April 2007 and March 2015. A total of LC-AB was 52 patients. LC-AB was determined using thin slice computed tomography (CT) imaging and pathological findings. Survival analysis was calculated using the Kaplan-Meier method. We used a Cox proportional hazards model for the univariate and multivariate analysis to identify prognostic factors. Results: The LC-AB group showed a higher frequency of younger patients (P=0.017), former or current smokers (P=0.011), men (P=0.021), tumor location in the upper lobe (P=0.031), moderately or poorly differentiated tumor histology (P vs . 74.9%, P=0.010, 75.4% vs . 61.3%, P=0.030, respectively). Multivariate analysis using a Cox proportional hazard model of OS showed that LC-AB was an independent prognostic factor [hazard ratio (HR): 0.30, 95% confidence interval (CI): 0.12–0.77, P=0.012]. Conclusions: Patients with LC-AB had better OS than those with non-LC-AB. Thus, LC-AB may be an independent favorable prognostic factor following curative resection. |
| Databáze: | OpenAIRE |
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