Elevation of HHV-6 viral load mimicking HHV-6 reactivation after second umbilical cord blood transplantation in chromosomally integrated human herpesvirus-6
| Autor: | Arisa Yamada, Michiyo Asano, Tatsuya Inukai, Seiichiro Yoshizawa, Daigo Akahane, Shigeki Nakamura, Mitsuru Moriyama, Hiroaki Fujimoto, Akihiko Gotoh, Nahoko Furuya, Seiichiro Katagiri, Shunsuke Otsuki, Akiko Yamada, Yuko Tanaka, Moritaka Gotoh |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Microbiology (medical) viruses medicine.medical_treatment Herpesvirus 6 Human Virus Integration 030106 microbiology Roseolovirus Infections Hematopoietic stem cell transplantation Genome Germline 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Medicine Humans Pharmacology (medical) 030212 general & internal medicine business.industry Umbilical Cord Blood Transplantation Hematopoietic Stem Cell Transplantation virus diseases biochemical phenomena metabolism and nutrition Viral Load medicine.disease Leukemia Infectious Diseases chemistry Immunology DNA Viral Cord Blood Stem Cell Transplantation Complication business Viral load DNA |
| Zdroj: | Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 27(10) |
| ISSN: | 1437-7780 |
| Popis: | Human herpesvirus-6 (HHV-6) reactivation is an important complication in patients receiving umbilical cord blood transplantation (CBT). Chromosomally integrated human herpesvirus-6 (ciHHV-6) is a condition in which the complete HHV-6 genome is integrated into the host germline genome and is transmitted in a Mendelian manner. The influence of ciHHV-6 in recipients or donors in cases of CBT is unknown. We report the first case with ciHHV-6 that received CBT twice for acute lymphoblastic T-cell leukemia. HHV-6 DNA in peripheral blood leukocytes (PBLs) was examined over time through two CBTs. After the first CBT, the HHV-6 viral load was significantly reduced by conversion to PBLs derived from the first donor. During the second CBT, an increase in HHV-6 DNA in PBLs and plasma were observed. However, HHV-6 mRNA was not detected in either the sample before 2nd CBT or at the time of HHV-6 DNA elevation. It is considered that the HHV-6 DNA detected in PBLs and plasma samples might be the HHV-6 genome released due to tissue damage. This case suggests that physicians should be aware of HHV-6 DNA variability during allogeneic hematopoietic stem cell transplantation in ciHHV-6 patients. |
| Databáze: | OpenAIRE |
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