Monoclonal antibodies against antigens on breast cancer cells
| Autor: | C. Stähli, H. Carmann, V. Miggiano, T. Stachelin, Bela Takacs |
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| Rok vydání: | 1985 |
| Předmět: |
Male
Pathology medicine.medical_specialty medicine.drug_class Fluorescent Antibody Technique Breast Neoplasms Spleen Biology Monoclonal antibody Epitope Cell Line Epitopes Mice Cellular and Molecular Neuroscience Antigen Antibody Specificity Antigens Neoplasm In vivo medicine Carcinoma Animals Humans Molecular Biology Pharmacology Mice Inbred BALB C Hybridomas Cell fusion Histocytochemistry Antibodies Monoclonal Cell Biology Fibroblasts medicine.disease Molecular biology medicine.anatomical_structure Cell culture Molecular Medicine Female |
| Zdroj: | Experientia. 41:1377-1381 |
| ISSN: | 1420-9071 0014-4754 |
| DOI: | 10.1007/bf01949996 |
| Popis: | Of 360 mAb obtained in a cell fusion experiment with the spleen cells of a mouse immunized with a mixture of different human breast carcinoma cells lines, 30 mAb were selected which reacted more strongly with tumor cells than with (noncancerous) fibroblasts. Theses mAb were tested for reactivity with additional types of cancerous and noncancerous tissues. Two mAb showed high tumor selectivity, but the corresponding epitopes on individual tumor cells were heterogeneously expressed. The mAb will be evaluated for in vivo applications. |
| Databáze: | OpenAIRE |
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