Non-organ-specific autoantibodies in nonalcoholic fatty liver disease: prevalence and correlates
| Autor: | Francesco B. Bianchi, Lucia Carulli, Amedeo Lonardo, F. Leonardi, Marco Bertolotti, Nicola Carulli, A. Borsatti, A. Bagni, Cristina Fontana, Paolo Muratori, D. Ganazzi, Paola Loria, Fabio Cassani, A.M. Verrone |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male medicine.medical_specialty Physiology medicine.medical_treatment Population autoimmunity autoimmune hepatitis liver biopsy NASH NOSA Mitochondria Liver Autoimmune hepatitis Insulin resistance Seroepidemiologic Studies Internal medicine Nonalcoholic fatty liver disease medicine Humans education Aged Autoantibodies education.field_of_study medicine.diagnostic_test business.industry Insulin Gastroenterology Autoantibody Muscle Smooth Hepatology Middle Aged medicine.disease Fatty Liver Endocrinology Liver biopsy Female Insulin Resistance business |
| Zdroj: | Digestive diseases and sciences. 48(11) |
| ISSN: | 0163-2116 |
| Popis: | Eighty-four consecutive subjects with nonalcoholic fatty liver disease (NAFLD) were tested for non-organ-specific autoantibodies (NOSA) by indirect immunoflorescence. Indices of insulin resistance and biochemical and anthropometric parameters were assessed. The overall prevalence of anti-nuclear-antibodies (ANA), smooth muscle antibodies (SMA) and anti-mitochondrial-antibodies (AMA) was 35.7% (30/84), 18 subjects (21.4%) being positive for ANA, 4 (4.7%) for SMA, 6 for ANA and SMA, and 2 for AMA. NOSA-positive subjects were older (P < 0.01) and mostly females (63.3%). No significant difference was found in the age-corrected parameters studied, except for copper and ceruloplasmin, which was more elevated in NOSA-positive patients. The subset of high titer (≥1:100) ANA-positive patients had significantly (P < 0.05) greater insulin resistance than ANA-negative patients. In contrast, SMA-positive patients had higher gammaglobulin and significantly lower insulin resistance as compared to high-titer ANA-positive patients. In 3 NOSA-positive but not in NOSA-negative patients, liver biopsy disclosed features of overlapping NASH with autoimmune hepatitis, partially responding to diet combined with steroid treatment. In conclusion, NOSA positivity in NAFLD is more prevalent than in the general population. High-titre ANA but not SMA positivity is associated with insulin resistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink