Evaluation of a near-infrared light ultrasound system as a non-invasive blood glucose monitoring device
| Autor: | Vera Herrmann, Anne Windjäger, Svenja Meyhöfer, Hannes Kalscheuer, Hendrik Lehnert, Andrej Augustinov, Flavia Ihling, Sebastian M. Schmid, Britta Wilms |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Endocrinology Germany Internal Medicine Medicine Humans Red light Blood glucose monitoring Reproducibility Near infrared light medicine.diagnostic_test business.industry Blood Glucose Self-Monitoring Ultrasound Non invasive Reproducibility of Results Gold standard (test) Glucose Tolerance Test Diabetes Mellitus Type 1 Intravenous Glucose Tolerance Test business Nuclear medicine |
| Zdroj: | Diabetes, obesitymetabolismREFERENCES. 22(4) |
| ISSN: | 1463-1326 |
| Popis: | The aim of this study was to evaluate the newly developed non-invasive blood glucose system NIRLUS® (Near-Infra Red Light Ultra Sound; NIRLUS Engineering AG, Lubeck, Germany) under standardized conditions. Seventeen healthy men of normal weight (body mass index 22.4 ± 1.4 kg/m2 ), aged 18 to 45 years, were enrolled in this study. During an intravenous glucose tolerance test, blood glucose profiles were measured simultaneously using the NIRLUS system and a "gold standard" laboratory reference system. Correlation analysis revealed a strong association between NIRLUS and reference values (r = 0.934; P < 0.001). Subsequent Bland-Altman analysis showed a symmetric distribution (r = 0.047; P = 0.395), and 95.5% of the NIRLUS-reference pairs were within the difference (d) of d ± 2 SD. The median deviation of all paired NIRLUS-reference values was 0.5 mmol/L and the mean percent deviation was 11.5%. Error grid analysis showed that 93.6% of NIRLUS-reference pairs are located in the area A, and 6.4% in the area B. No data were allocated in the areas C to E. This proof-of-concept study demonstrates the reproducibility of accurate blood glucose measures obtained by NIRLUS as compared to a gold standard laboratory reference system. The technology of NIRLUS is an important step forward in the development of non-invasive glucose monitoring. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text