Evaluation of COX-2, EGFR, and p53 as biomarkers of non-dysplastic oral leukoplakias
| Autor: | Manuel Valladares Ayerbes, Ramón Luaces Rey, Luis M. Antón Aparicio, Vanessa Medina Villaamil, José Luis López Cedrún, Augusto Álvarez García, Silvia Díaz Prado |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male p53 Oncology medicine.medical_specialty Pathology Biopsy EGFR Clinical Biochemistry Molecular marker Biology Pathology and Forensic Medicine Lesion Internal medicine Oral and maxillofacial pathology medicine Humans Molecular Biology Aged Leukoplakia Aged 80 and over medicine.diagnostic_test Surrogate endpoint Mouth Mucosa Case-control study Anatomical pathology Oral leukoplakia Middle Aged COX-2 medicine.disease Quantitative real-time PCR ErbB Receptors stomatognathic diseases Real-time polymerase chain reaction Cyclooxygenase 2 Case-Control Studies Female Leukoplakia Oral Tumor Suppressor Protein p53 medicine.symptom Biomarkers |
| Zdroj: | RUC. Repositorio da Universidade da Coruña instname |
| ISSN: | 0014-4800 |
| DOI: | 10.1016/j.yexmp.2010.06.004 |
| Popis: | [Abstract] Objective. Identify candidate SEBs (surrogate endpoint biomarkers) for premalignant trends in head and neck mucosa. Study design. Study, by qPCR (quantitative real-time polymerase chain reaction), the expression of COX-2, EGFR and p53 in 24 biopsies of non-dysplastic oral leukoplakia and contra-lateral normal-appearing mucosa. Results. COX-2 was up-regulated in leukoplakia (79.2%); whereas EGFR and p53 were up-regulated (p > 0.05) in oral contra-lateral normal-appearing mucosa (60% and 46% respectively). Also, p53 expression was correlated with tobacco smoke habits and Spearman's rank correlation coefficient showed a positive linear correlation between p53 and EGFR mRNA expression levels. Conclusions. COX-2 would serve as SEB of oral leukoplakia. The results suggest that p53 appears to be one of the molecular targets of tobacco-related carcinogens in leukoplakia and that the co-expression of p53 and EGFR may play a role in this kind of oral pre-cancerous lesion. More detailed studies of EGFR and p53 should be continued in the future. |
| Databáze: | OpenAIRE |
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