CATASTROPHIC ANTIPHOSPHOLIPID SYNDROME AND POSTERIOR OCULAR INVOLVEMENT
| Autor: | Véronique Le Guern, Cécile Yelnik, Bertrand Godeau, Hanane Mehawej, Clémence Bonnet, Mathilde Roumier, Marc Lambert, Julien Haroche, Nathalie Morel, Ygal Benhamou, Laurent Perard, Antoine P. Brézin, Nicolas Maillard, Bahram Bodaghi, Jean-Charles Piette, Nathalie Costedoat-Chalumeau |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Visual acuity Adolescent Fundus Oculi Vision Disorders Visual Acuity Age at diagnosis Catastrophic antiphospholipid syndrome Severity of Illness Index Young Adult Ophthalmology Humans Medicine Fluorescein Angiography Aged Retrospective Studies Retinal Vascular Occlusion business.industry Retinal vasculitis General Medicine Middle Aged Antiphospholipid Syndrome medicine.disease Posterior segment of eyeball Female medicine.symptom business Vasculitis Tomography Optical Coherence Retinopathy |
| Zdroj: | Retina. 41:2332-2341 |
| ISSN: | 0275-004X |
| Popis: | PURPOSE To describe the posterior ophthalmic manifestations of catastrophic antiphospholipid syndrome. METHODS Retrospective case series of patients presenting with catastrophic antiphospholipid syndrome and posterior segment ocular manifestations. The main outcomes were the type of posterior segment manifestations at catastrophic antiphospholipid syndrome diagnosis, specifically retinal vascular occlusion, vasculitis, or choroidopathy, and the final best-corrected visual acuity. RESULTS This study included 23 patients (11 cases treated by the authors and 12 published case reports); 21 (91%) of them female. Their median age at diagnosis was 28 years (range, 16-79 years). Ophthalmologic manifestations were usually bilateral (n = 19, 83%) and involved vascular occlusive retinopathy (n = 17, 74%), choroidopathy (n = 11, 48%), or retinal vasculitis (n = 1, 4%). Final best-corrected visual acuity was not significantly worse than the best-corrected visual acuity at diagnosis (P = 0.16). Retinal vascular occlusions were associated with poorer final visual acuity than choroidopathy (P = 0.002). After a median follow-up of 14 months (range, 2-132 months), nearly half the patients (n = 11, 48%) had permanent vision loss including best-corrected visual acuity of |
| Databáze: | OpenAIRE |
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