Family association study between DRD2 and DRD3 gene polymorphisms and schizophrenia in a Portuguese population
| Autor: | Fabio Macciardi, José Valente, António Macedo, Alda M. Ambrósio, Carlos N. Pato, A. Dourado, Catarina R. Oliveira, James L. Kennedy |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Candidate gene Linkage disequilibrium Psychosis Gene Expression Biology Candidate genes Catchment Area Health Dopamine receptor D3 medicine Humans Biological Psychiatry Genetic association Genetics Polymorphism Genetic Portugal Receptors Dopamine D2 Haplotype Receptors Dopamine D3 Transmission disequilibrium test medicine.disease Association study Diagnostic and Statistical Manual of Mental Disorders Psychiatry and Mental health Haplotypes Schizophrenia Female |
| Zdroj: | Repositório Científico de Acesso Aberto de Portugal Repositório Científico de Acesso Aberto de Portugal (RCAAP) instacron:RCAAP |
| ISSN: | 0165-1781 |
| Popis: | Schizophrenia is a highly heritable condition, as demonstrated in family, twin and adoption studies. Candidate genes from the dopaminergic system have long been hypothesized to be involved in the etiology of this disorder. In the present study, we investigated the genetic association between polymorphisms in the D2 and D3 dopamine receptor (DRD2, DRD3) genes and schizophrenia. We examined 90 trios from Portugal, and negative results were obtained from association studies with both Haplotype Relative Risk (HRR) and Transmission Disequilibrium Test (TDT), as well as TRANSMIT. Therefore, we conclude that neither the DRD2 nor the DRD3 gene polymorphisms investigated are associated with schizophrenia in our sample. http://www.sciencedirect.com/science/article/B6TBV-4C41P80-1/1/d79d43eb85579e44d4d3d0a2d108cf4a |
| Databáze: | OpenAIRE |
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