The aberrant overexpression of vimentin is linked to a more aggressive status in tumours of the gastrointestinal tract
| Autor: | Mateusz Sitarski, Izabela Kołodziej, Marlena Brzozowa, Małgorzata Żaba, Natalia Matysiak, Romuald Wojnicz, Grzegorz Wyrobiec, Edyta Reichman-Warmusz |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Gastrointestinal tract Review Paper biology business.industry Cadherin Mesenchymal stem cell Gastroenterology E-cadherin Vimentin Lymph node metastasis macromolecular substances vimentin gastrointestinal tumours medicine biology.protein Intermediate Filament Protein business Myofibroblast Vimentin expression |
| Zdroj: | Przegla̜d Gastroenterologiczny |
| ISSN: | 1897-4317 1895-5770 |
| Popis: | Vimentin is an intermediate filament protein normally expressed in cells of mesenchymal origin, e.g. myofibroblasts, chondrocytes, macrophages, and endothelial cells. The expression of vimentin, which has been thought of as the main mesenchymal marker, is also detected in tumour tissue. In tumours of the gastrointestinal tract vimentin expression is usually correlated with advanced stage of tumour, lymph node metastasis, and patient survival. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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