Preparation of a dibenzylated 1,4-diazacyclohexane-derived strong anion-exchange stationary phase
| Autor: | Chao Li, Juxiang Ruan, Zhijian Zeng, Qiwei Lang, Xiongjun Zuo |
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| Rok vydání: | 2013 |
| Předmět: |
Anions
Aza Compounds Chromatography Chemistry Elution Methanol Organic Chemistry General Medicine Hydrogen-Ion Concentration Chromatography Ion Exchange Silicon Dioxide Biochemistry Dissociation (chemistry) Analytical Chemistry Ion Solvent chemistry.chemical_compound Benzyl chloride Isomerism Stationary phase Cyclohexanes Benzene Derivatives Selectivity |
| Zdroj: | Journal of chromatography. A. 1297 |
| ISSN: | 1873-3778 |
| Popis: | This paper reports the preparation of a novel, silica-based, strong anion-exchange stationary phase from a 1,4-diazacyclohexane derivative. To prepare the difunctional strong anion-exchange stationary phase, activated silica beads were first bonded with 3-chloropropyltriethoxysilane and then reacted with 1-methylpiperazine followed by benzyl chloride. The silica beads, the strong anion-exchange stationary phase and its precusors were instrumentally characterized. Aromatic acids were separated with non-aqueous anion-exchange chromatography. After elution with eluant prepared in mixed solvents of water and methanol, the resulting 1,4-diazacyclohexane-derived, difunctional, strong anion-exchange stationary phase exhibited good separation and selectivity for the aromatic acids investigated. The effects of eluant pH, eluant ion concentration and solvent composites on the separations were investigated. Organic acids with different substituents were eluted in order of decreasing dissociation coefficients, with no observable peak shape differences. |
| Databáze: | OpenAIRE |
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