| Popis: |
Celiac disease (CD), an immune-mediated enteropathy, has a clinical spectrum that is remarkably wide including neuropsychiatric manifestations. While studies of adults have shown sleep disturbances, there is limited data in children. Our objectives were to assess the association between sleep disturbances and CD in children, and the effect of a gluten-free diet (GFD).Parents of children 3 to 12 years old, referred for endoscopy, completed the Sleep Disturbance Scale for Children (SDSC) and modified Epworth Sleepiness Scale (mESS). Children with CD were compared with healthy controls and children with abdominal pain but no definitive findings on investigation (AP). Parents of children with CD and AP were contacted after 6 months for follow up.We enrolled 101 subjects, mean age 6.5 (2.8), 51% female, 38 with CD, 18 AP, and 45 healthy. SDSC scores were 37.4 (8.7), 41.3 (11.3) and 45.4 (13.7) in healthy controls, CD and AP respectively (p=0.024). There was a significant difference in the disorders of arousal domain (p=0.044). There were no significant differences on the mESS. A trend toward improvement in SDSC scores was seen in children with CD presenting with abdominal pain after 6 months on a GFD (p=0.07).In this first prospective study of sleep disturbances in children with CD, we show high rates of disturbed sleep compared with healthy children. Sleep disturbances did not improve on a GFD but may be driven by abdominal pain. |
