The role of the organ microenvironment in the biology and therapy of cancer metastasis
| Autor: | Isaiah J. Fidler, Sun Jin Kim, Robert R. Langley |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Angiogenesis
Cancer metastasis Host factors Biology Biochemistry Metastasis Pathogenesis Neovascularization Interferon-gamma Neoplasms medicine Animals Humans Tumor growth Neoplasm Invasiveness Neoplasm Metastasis Molecular Biology Regulation of gene expression Neovascularization Pathologic Cell Biology medicine.disease Gene Expression Regulation Neoplastic Immunology Cancer research Fibroblast Growth Factor 2 medicine.symptom |
| Zdroj: | Journal of cellular biochemistry. 101(4) |
| ISSN: | 0730-2312 |
| Popis: | By the time of diagnosis, primary neoplasms are biologically heterogeneous and contain subpopulations of cells with different metastatic potentials. The pathogenesis of a metastasis consists of many sequential steps that must be completed to produce clinically relevant lesions. During any of these steps, tumor cells interact with host factors in the microenvironment that the tumor cells can usurp. Treatment of metastasis can be directed against tumor cells and/or microenvironmental factors that support tumor growth, such as tumor-associated blood vessels. |
| Databáze: | OpenAIRE |
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