Effects of excessive glucocorticoid receptor stimulation during early gestation on psychomotor and social behavior in the rat
| Autor: | Karine Kleinhaus, Leora Goodman, Dolores Malaspina, Holly Moore, Jordan Balaban, Tara K.S. Craft, Michael M. Myers, Sara Steinfeld |
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| Rok vydání: | 2010 |
| Předmět: |
Male
Reflex Startle medicine.medical_specialty Offspring Motor Activity Article Dexamethasone Behavioral Neuroscience Receptors Glucocorticoid Glucocorticoid receptor Developmental Neuroscience Pregnancy Internal medicine Developmental and Educational Psychology medicine Animals Rats Wistar Maternal Behavior Social Behavior Glucocorticoids Maternal-Fetal Exchange Analysis of Variance Behavior Animal Sensory Gating medicine.disease Startle reaction Play and Playthings Rats Amphetamine medicine.anatomical_structure Endocrinology Prenatal stress Prenatal Exposure Delayed Effects Gestation Female Stereotyped Behavior Psychology Glucocorticoid Hypothalamic–pituitary–adrenal axis Developmental Biology medicine.drug |
| Zdroj: | Developmental Psychobiology. |
| ISSN: | 1098-2302 0012-1630 |
| DOI: | 10.1002/dev.20419 |
| Popis: | Severe psychological stress in the first trimester of pregnancy increases the risk of schizophrenia in the offspring. To begin to investigate the role of glucocorticoid receptors in this association, we determined the effects of the glucocorticoid dexamethasone (2 mg/kg), administered to pregnant rats on gestation days 6-8, on maternal behaviors and schizophrenia-relevant behaviors in the offspring. Dams receiving dexamethasone exhibited increased milk ejection bouts during nursing. Offspring of dexamethasone-treated dams (DEX) showed decreased juvenile social play and a blunted acoustic startle reflex in adolescence and adulthood, effects that were predicted by frequency of milk ejections in the dams. DEX offspring also showed increased prepulse inhibition of startle and reduced amphetamine-induced motor activity, effects not correlated with maternal behavior. It is postulated that over-stimulation of receptors targeted by glucocorticoids in the placenta or other maternal tissues during early gestation can lead to psychomotor and social behavioral deficits in the offspring. Moreover, some of these deficits may be mediated by alterations in postnatal maternal behavior and physiology produced by early gestational exposure to excess glucocorticoids. |
| Databáze: | OpenAIRE |
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