Efficacy of Leucocyte-Poor Red Blood Cell Suspensions Prepared by Sedimentation in Hydroxyethyl Starch
| Autor: | J. A. Moore, I. Dorner, Hugh Chaplin, J. A. Collins, L. A. Sherman |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Erythrocytes Time Factors Starch Immunology Blood Sedimentation Cell Separation Biology Hydroxyethyl starch Hydroxyethyl Starch Derivatives Leukocyte Count chemistry.chemical_compound White blood cell Leukocytes medicine Humans Immunology and Allergy Whole blood Chromatography Temperature Dextrans Hematology Red blood cell medicine.anatomical_structure Dextran Biochemistry chemistry Erythrocyte Count Female Packed red blood cells medicine.drug |
| Zdroj: | Transfusion. 15:439-448 |
| ISSN: | 0041-1132 |
| DOI: | 10.1046/j.1537-2995.1975.15576082218.x |
| Popis: | Hydroxyethyl starch (HES), which is licensed for human use as a plasma volume expander, has red blood cell sedimenting properties similar to high molecular weight dextran (HMWD). The present studies document the effectiveness of commercially available HES in preparing leukocyte-poor red blood cell suspensions (L-PRBCs) from donor whole blood and packed red blood cells stored in CPD up to 120 hours prior to processing. The effect of HES sedimentation on final white blood cell count, on erythrocyte p50 and 2,3-DPG concentration, and on short- and long-term in vivo survival of 72-hour stored donor red cells are described, along with favorable clinical experience with over 300 transfusions of HES-sedimented L-PRBCs. Since the method requires no special equipment, it is immediately available for widespread use. |
| Databáze: | OpenAIRE |
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