4-Phenyl-1-(prop-2-yn-1-yl)-1H-1,5-benzodiazepin-2(3H)-one
| Autor: | José A. S. Cavaleiro, Mohamed Essaber, José A. Fernandes, Abdesselam Baouid, Mohamed Loughzail, Filipe A. Almeida Paz |
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| Rok vydání: | 2011 |
| Předmět: |
Aqueous solution
Substituent General Chemistry Dihedral angle 010402 general chemistry 010403 inorganic & nuclear chemistry Condensed Matter Physics Bioinformatics Organic Papers 01 natural sciences Medicinal chemistry 0104 chemical sciences 3. Good health Catalysis lcsh:Chemistry chemistry.chemical_compound lcsh:QD1-999 chemistry Amide Propargyl General Materials Science Propargyl bromide Derivative (chemistry) |
| Zdroj: | Acta Crystallographica Section E, Vol 67, Iss 8, Pp o2075-o2076 (2011) Acta Crystallographica Section E: Structure Reports |
| ISSN: | 1600-5368 |
| Popis: | 4-Phenyl-1H-1,5-benzodiazepin-2(3H)-one reacts in the presence of a concentrated aqueous solution of sodium hydroxide and a quaternary ammonium salt (as catalyst) in benzene (phase transfer catalysis) with propargyl bromide, affording the title benzodiazepine derivative, C18H14N2O. In the molecule, the mean plane of the propargyl substituent is almost perpendicular with that of the amide group [dihedral angle = 87.81 (8)°]. In the crystal, the molecules are linked by C—H...O and C—H...N interactions. |
| Databáze: | OpenAIRE |
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