Urinary Excretion and Metabolism of Arbutin after Oral Administration of Arctostaphylos uvae ursi Extract as Film-Coated Tablets and Aqueous Solution in Healthy Humans
| Autor: | G Schindler, Markus Veit, Jörg Wittig, Ulrich Patzak, Nils Krähmer, B Brinkhaus, Ingmar Glöckl, Alexander Von Nieciecki |
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| Rok vydání: | 2002 |
| Předmět: |
Adult
Male Metabolite Administration Oral Urine chemistry.chemical_compound Pharmacokinetics Humans Pharmacology (medical) Bearberry Antibacterial agent Pharmacology Cross-Over Studies Chromatography Hydroquinone Plant Extracts Arbutin Hydroquinones Bioavailability Plant Leaves Solutions Arctostaphylos chemistry Female Phytotherapy Tablets |
| Zdroj: | The Journal of Clinical Pharmacology. 42:920-927 |
| ISSN: | 0091-2700 |
| Popis: | Bearberry leaves and preparations made from them are traditionally used for urinary tract infections. The urinary excretion of arbutin metabolites was examined in a randomized crossover design in 16 healthy volunteers after the application of a single oral dose of bearberry leaves dry extract (BLDE). There were two groups of application using either film-coated tablets (FCT) or aqueous solution (AS). The urine sample analysis was performed by a validated HPLC coolarray method (hydroquinone) and a validated capillary electrophoresis method (hydroquinone-glucuronide, hydroquinone-sulfate). The total amounts of hydroquinone equivalents excreted in the urine from BLDE were similar in both groups. With FCT, 64.8% of the arbutin dose administered was excreted; with AS, 66.7% was excreted (p = 0.61). The maximum mean urinary concentration of hydroquinone equivalents was a little higher and peaked earlier in the AS group versus the FCT group, although this did not reach statistical significance (Cur max = 1.6893 micromol/ml vs. 1.1250 micromol/ml, p = 0.13; tmax (t midpoint) = 3.60 h vs. 4.40 h, p = 0.38). The relative bioavailability of FCT compared to AS was 103.3% for total hydroquinone equivalents. There was substantial intersubject variability. No significant differences between the two groups were found in the metabolite patterns detected (hydroquinone, hydroquinone-glucuronide, and hydroquinone-sulfate). |
| Databáze: | OpenAIRE |
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