The amino acid sensitive TOR pathway from yeast to mammals
| Autor: | George Thomas, Stephen G. Dann |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Saccharomyces cerevisiae Proteins
Amino acid transport Biophysics P70-S6 Kinase 1 Protein Serine-Threonine Kinases Biochemistry mTORC2 Leucine Structural Biology Genetics Animals Insulin Amino Acids Molecular Biology PI3K/AKT/mTOR pathway chemistry.chemical_classification biology TOR Serine-Threonine Kinases RPTOR Cell Biology hVPS34 Amino acid chemistry Models Animal mTOR biology.protein Protein Kinases Signal Transduction RHEB |
| Zdroj: | FEBS Letters. 580:2821-2829 |
| ISSN: | 0014-5793 |
| Popis: | The target of rapamycin (TOR) is an ancient effector of cell growth that integrates signals from growth factors and nutrients. Two downstream effectors of mammalian TOR, the translational components S6K1 and 4EBP1, are commonly used as reporters of mTOR activity. The conical signaling cascade initiated by growth factors is mediated by PI3K, PKB, TSC1/2 and Rheb. However, the process through which nutrients, i.e., amino acids, activate mTOR remains largely unknown. Evidence exists for both an intracellular and/or a membrane bound sensor for amino acid mediated mTOR activation. Research in eukaryotic models, has implicated amino acid transporters as nutrient sensors. This review describes recent advances in nutrient signaling that impinge on mTOR and its targets including hVps34, class III PI3K, a transducer of nutrient availability to mTOR. |
| Databáze: | OpenAIRE |
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