A possible vulnerability locus for bipolar affective disorder on chromosome 21q22.3
Autor: | Richard E. Straub, Thomas Lehner, Ying Luo, Jo Ellen Loth, Wei Shao, Lawrence Sharpe, Joyce R. Alexander, Kamna Das, Robert Simon, Ronald R. Fieve, Bernard Lerer, Jean Endicott, Jurg Ott, T. Conrad Gilliam, Miron Baron |
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Rok vydání: | 1994 |
Předmět: |
Adult
Genetic Markers Male Bipolar Disorder Adolescent Chromosomes Human Pair 21 Locus (genetics) Biology Gene Frequency Gene mapping Genetics medicine Humans Genetic Predisposition to Disease Bipolar disorder Gene Allele frequency Alleles Aged Phenocopy Chromosome Mapping Middle Aged medicine.disease Penetrance Pedigree Female Lod Score medicine.symptom Mania |
Zdroj: | Nature Genetics. 8:291-296 |
ISSN: | 1546-1718 1061-4036 |
Popis: | In a preliminary genome scan of 47 bipolar disorder families, we detected in one family a lod score of 3.41 at the PFKL locus on chromosome 21q22.3. The lod score is robust to marker allele frequencies, phenocopy rates and age-dependent penetrance, and remains strongly positive with changes in affection status. Fourteen other markers in 21q22.3 were tested on this family, with largely positive lod scores. Five of the other 46 families also show positive, but modest lod scores with PFKL. When all 47 families are analysed together, there is little support for linkage to PFKL under homogeneity or heterogeneity using lod score analysis, but the model-free affected-pedigree-member method yields statistically significant results (p |
Databáze: | OpenAIRE |
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