Comparative study of the action of flunixin meglumine and tolfenamic acid on prostaglandin E2synthesis in bovine inflammatory exudate
| Autor: | S. Dalle, J. Espinasse, J. Garcia, J. P. Thouvenot, S. Daval, Jean-Francois Valarcher, O. Salat, François Schelcher |
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| Rok vydání: | 1994 |
| Předmět: |
Male
Inflammation Stimulation Pharmacology Carrageenan Placebo Dinoprostone Random Allocation chemistry.chemical_compound Tolfenamic acid medicine Animals ortho-Aminobenzoates Prostaglandin E2 General Veterinary Anti-Inflammatory Agents Non-Steroidal Granulation tissue Radioimmunoassay Exudates and Transudates Clonixin Disease Models Animal medicine.anatomical_structure chemistry Anesthesia Cattle medicine.symptom medicine.drug |
| Zdroj: | Journal of Veterinary Pharmacology and Therapeutics. 17:271-274 |
| ISSN: | 1365-2885 0140-7783 |
| DOI: | 10.1111/j.1365-2885.1994.tb00244.x |
| Popis: | An acute non-immune inflammation model was used to compare the action of two non-steroidal anti-inflammatory drugs, flunixin meglumine and tolfenamic acid, on prostaglandin E2 (PGE2) synthesis in bovine inflammatory exudate. The tissue cage model used involves subcutaneous implantation of polypropylene cages and subsequent stimulation by carrageenan injection of the granulation tissue which develops within the cage. Twelve calves were randomly assigned to three groups receiving placebo, flunixin meglumine and tolfenamic acid, respectively. Inflammatory exudate was sampled 30 min after carrageenan injection and at seven subsequent time points. PGE2 levels were determined by radioimmunoassay. At each time point post-carrageenan injection, flunixin meglumine inhibited PGE2 synthesis to a greater extent than tolfenamic acid. At 4, 8, 12 and 24 h these differences were statistically significant. |
| Databáze: | OpenAIRE |
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