Diagnosis Accuracy of Transcutaneous Bilirubinometry in Very Preterm Newborns
| Autor: | Sylvain Samperiz, Maya Gebus, Thierry Debillon, Chloé Epiard, Anne Ego, Amandine Rubio, Michel Deiber, Céline Genty |
|---|---|
| Přispěvatelé: | Grenoble Institut des Neurosciences (GIN), Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Centre hospitalier Félix-Guyon [Saint-Denis, La Réunion], Techniques pour l'Evaluation et la Modélisation des Actions de la Santé (TIMC-IMAG-ThEMAS), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Registre des Handicaps de l'Enfant et Observatoire Périnatal Isère, RHEOP |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
Male
Time Factors MESH: Logistic Models MESH: Phototherapy chemistry.chemical_compound 0302 clinical medicine MESH: Bilirubin MESH: Gestational Age 030212 general & internal medicine Prospective Studies Prospective cohort study Obstetrics MESH: Infant Extremely Premature MESH: Infant Newborn Gestational age Jaundice MESH: Predictive Value of Tests 3. Good health Jaundice Neonatal Very preterm Predictive value of tests Infant Extremely Premature Female France medicine.symptom Blood drawing medicine.medical_specialty Bilirubin MESH: Jaundice Neonatal education Gestational Age MESH: Multivariate Analysis 03 medical and health sciences Neonatal Screening Predictive Value of Tests 030225 pediatrics medicine Humans MESH: Neonatal Screening Transcutaneous bilirubin MESH: Humans business.industry MESH: Time Factors Infant Newborn Phototherapy MESH: Prospective Studies MESH: Male MESH: France Logistic Models chemistry Pediatrics Perinatology and Child Health Multivariate Analysis [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie business MESH: Female Developmental Biology |
| Zdroj: | Neonatology Neonatology, Karger, 2016, 111 (1), pp.1-7. ⟨10.1159/000447736⟩ |
| ISSN: | 1661-7800 1661-7819 |
| Popis: | Background: Transcutaneous bilirubin (TcB) is a validated test for systematic screening of neonatal hyperbilirubinemia and monitoring term and near-term infants under phototherapy. Objectives: To evaluate TcB diagnostic accuracy for very preterm neonates. Methods: Total serum bilirubin (TSB) and TcB measurements were performed prospectively in a multicenter sample of newborns Results: Altogether, 481 measurements were analyzed in 167 preterm patients. Mean GA was 27.6 ± 1.6 weeks. The rates of newborns requiring phototherapy were 52% in the first 3 days, 16% from the 4th to the 7th day, and 2% during the second week. Diagnostic performance was similar among babies with or without phototherapy. TcB sensitivity decreased over time from 100% (93.9-100.0) to 50% (1.3-98.7). Specificity showed an inverse evolution from 14.8% (7.0-26.2) to 80.7% (72.2-89.2). The best performance was that of negative predictive values which varied from 95.5 to 100.0. False negatives were rare throughout the study (0.8% of measurements). In a multivariate analysis, the only factor significantly influencing discordance between TcB and TSB was postnatal age. We did not find any impact of GA and skin color. Conclusion: Among very preterm babies, TcB measurements might be useful for screening for neonatal jaundice in the first 2 weeks of life. In case of a TcB value below the phototherapy threshold, invasive TSB quantification could be unnecessary, with potential avoidance of blood drawing. |
| Databáze: | OpenAIRE |
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