Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspective
| Autor: | Roelf Valkema, Willem H. Bakker, P. P. M. Kooij, Theo J. Visser, Marion de Jong, Eric P. Krenning, Dik J. Kwekkeboom, Wout A.P. Breeman |
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| Přispěvatelé: | Radiology & Nuclear Medicine, Internal Medicine |
| Rok vydání: | 2001 |
| Předmět: |
endocrine system
Pathology medicine.medical_specialty Basic science Octreotide Lutetium Octreotida Lanreotide chemistry.chemical_compound Medicine Humans Radiology Nuclear Medicine and imaging Radionuclide imaging Yttrium Radioisotopes Receptors Somatostatin Radionuclide Imaging Octreotate Somatostatin receptor business.industry Indium Radioisotopes General Medicine Neuroendocrine Tumors Somatostatin chemistry Radiopharmaceuticals business Neuroscience hormones hormone substitutes and hormone antagonists medicine.drug |
| Zdroj: | European Journal of Nuclear Medicine, 28(9), 1421-1429. Springer-Verlag |
| ISSN: | 0340-6997 |
| Popis: | In vivo somatostatin receptor-mediated scintigraphy has proven to be a valuable method for the visualisation of neuroendocrine tumours and their metastases. A new application is the use of radiolabelled analogues for somatostatin receptor-mediated therapy. This paper presents a review on the basic science, historical background and current knowledge of somatostatin receptor subtypes and their expression in neuroendocrine tumours. New somatostatin analogues, new chelators, "new" radionuclides and combinations thereof are also discussed. Due attention is given to limitations and future perspectives of somatostatin receptor-mediated imaging and therapy. |
| Databáze: | OpenAIRE |
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