The modulation of gap-junctional intercellular communication by lipid rafts

Autor: Marc Mesnil, Norah Defamie
Přispěvatelé: Institut de physiologie et biologie cellulaires (IPBC), Université de Poitiers-Centre National de la Recherche Scientifique (CNRS)
Rok vydání: 2011
Předmět:
MESH: Signal Transduction
Models
Molecular
Protein Conformation
[SDV]Life Sciences [q-bio]
MESH: Gap Junctions
Biophysics
MESH: Membrane Microdomains
Connexin
Cell Communication
Biology
Caveolae
Biochemistry
Models
Biological
Connexins
03 medical and health sciences
MESH: Protein Conformation
Membrane Microdomains
Cell Movement
Neoplasms
MESH: Cell Communication
Animals
Humans
MESH: Animals
MESH: Neoplasms
Lipid raft
MESH: Cell Movement
030304 developmental biology
Cancer
0303 health sciences
MESH: Humans
030302 biochemistry & molecular biology
Gap junction
MESH: Models
Biological
Gap Junctions
Gap junctional intercellular communication
Cell Biology
Sphingolipid
MESH: Lipids
Lipids
Cell biology
MESH: Connexins
lipids (amino acids
peptides
and proteins)
Signalling pathways
Intracellular
MESH: Models
Molecular
Signal Transduction
Zdroj: Biochimica et Biophysica Acta:Biomembranes
Biochimica et Biophysica Acta:Biomembranes, Elsevier, 2012, 1818 (8), pp.1866-9. ⟨10.1016/j.bbamem.2011.09.023⟩
ISSN: 0006-3002
0005-2736
1879-2642
DOI: 10.1016/j.bbamem.2011.09.023⟩
Popis: International audience; Lipid rafts are specific microdomains of plasma membrane which are enriched in cholesterol and sphingolipids. These domains seem to favour the interactions of particular proteins and the regulation of signalling pathways in the cells. Recent data have shown that among the proteins, which are preferentially localized in lipid rafts, are connexins that are the structural proteins of gap junctions. Since gap junctional intercellular communication is involved in various cellular processes and pathologies such as cancer, we were interested to review the various observations concerning this specific localization of connexins in lipid rafts and its consequences on gap junctional intercellular communication capacity. In particular, we will focus our discussion on the role of the lipid raft-connexin connection in cancer progression. This article is part of a Special Issue entitled: The Communicating junctions, composition, structure and characteristics.
Databáze: OpenAIRE
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