Increased uric acid promotes decline of the renal function in hypertensive patients: a 10-year observational study
| Autor: | Kanako Kiyohara, Hideyuki Oniki, Yuko Ohta, Takuya Tsuchihashi |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Multivariate analysis Urinary system Urology Renal function Kidney Excretion chemistry.chemical_compound Internal Medicine medicine Humans Salt intake Risk factor Aged business.industry General Medicine Middle Aged Surgery Uric Acid chemistry Hypertension Uric acid Observational study Female business Glomerular Filtration Rate |
| Zdroj: | Internal medicine (Tokyo, Japan). 52(13) |
| ISSN: | 1349-7235 |
| Popis: | Objective Uric acid (UA) has shown to be a causal risk factor for the development and progression of renal disease. The aim of this study was to investigate the relationship between changes in the level of UA and trends in the renal function among hypertensive patients during a 10-year observation period. Methods The subjects included 104 hypertensive outpatients (60 women and 44 men, mean age 60±9 (SD) years at the first visit) who had undergone at least five instances of successful 24-hour home urine collection, with the first examination completed between 1998 and 2000 and the last examination completed between 2008 and 2010. Results The estimated glomerular filtration rate (eGFR) significantly decreased over the 10.4-year observation period, with an average change in eGFR of -0.66/mL/min/year. The uric acid clearance at the last examination was significantly lower than that observed at the first visit, while there were no significant differences in the serum UA levels during this period. The change in serum UA exhibited a significant negative correlation with the change in eGFR (r=-0.34, p |
| Databáze: | OpenAIRE |
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