Drug-naive patients with Parkinson's disease in Hoehn and Yahr stages I and II show a bilateral decrease in striatal dopamine transporters as revealed by [ 123 I]β-CIT SPECT
| Autor: | Erik Ch. Wolters, E. A. Van Royen, Jan Booij, P. Bergmans, Johannes C. Stoof, A. Winogrodzka, G. Tissingh |
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| Rok vydání: | 1997 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Parkinson's disease Dopamine Nerve Tissue Proteins Functional Laterality Iodine Radioisotopes Central nervous system disease Degenerative disease Cocaine Internal medicine medicine Humans Aged Dopamine transporter Tomography Emission-Computed Single-Photon Dopamine Plasma Membrane Transport Proteins Membrane Glycoproteins biology Putamen Dopaminergic Discriminant Analysis Membrane Transport Proteins Parkinson Disease Middle Aged medicine.disease Corpus Striatum Drug-naïve Endocrinology Neurology Case-Control Studies Disease Progression biology.protein Female Neurology (clinical) Carrier Proteins Psychology medicine.drug |
| Zdroj: | Journal of Neurology. 245:14-20 |
| ISSN: | 1432-1459 0340-5354 |
| Popis: | Ten healthy subjects and 16 patients with early Parkinson's disease (PD) were examined with single photon emission computed tomography (SPECT) and [123I]beta-CIT, a ligand for the dopamine (DA) transporter. Only drug-naive patients were examined since the expression of and binding to DA transporters may be influenced by dopaminergic medication. The main finding was a significant reduction in [123I]beta-CIT binding in the ipsi- and contralateral striatal regions, especially in the putamen, which showed a mean reduction of 65% of the control mean. Discriminant function analysis of the putaminal [123I]beta-CIT binding measures classified 100% of the cases in the correct group. Disease severity correlated negatively and highly significantly with the binding measures. Tremor ratings did not correlate with the SPECT measures, whereas rigidity, and to a lesser extent bradykinesia, did. Patients with unilateral PD showed a bilateral loss of striatal DA transporters. Our findings indicate that with [123I]beta-CIT SPECT it is possible to diagnose PD in subjects with very mild symptoms and signs. Moreover, finding a bilateral loss of striatal DA transporters in patients with unilateral PD also suggests that it may be possible to identify subjects in the preclinical phase of the disease. |
| Databáze: | OpenAIRE |
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