Influence of epileptogenic region on brain structural changes in Rolandic epilepsy
| Autor: | Qiang Xu, Fang Yang, Zheng Hu, Yan He, Qirui Zhang, Yin Xu, Zhiqiang Zhang, Guangming Lu, Junhao Xiao, Yifei Weng, Steven M. Stufflebeam |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Cognitive Neuroscience Audiology computer.software_genre Behavioral Neuroscience Cellular and Molecular Neuroscience Epilepsy Voxel Cortex (anatomy) medicine Humans Radiology Nuclear Medicine and imaging Gray Matter Child Neuroradiology Brain Mapping business.industry Neuropsychology Brain Human brain medicine.disease Executive functions Epilepsy Rolandic Magnetic Resonance Imaging humanities nervous system diseases Rolandic epilepsy Psychiatry and Mental health medicine.anatomical_structure Neurology Neurology (clinical) business human activities computer |
| Zdroj: | Brain Imaging and Behavior. 16:424-434 |
| ISSN: | 1931-7565 1931-7557 |
| DOI: | 10.1007/s11682-021-00517-5 |
| Popis: | To investigate the influence of epileptogenic cortex (Rolandic areas) with executive functions in Rolandic epilepsy using structural covariance analysis of structural magnetic resonance imaging (MRI). Structural MRI data of drug-naive patients with Rolandic epilepsy (n = 70) and typically developing children as healthy controls (n = 83) were analyzed using voxel-based morphometry. Gray matter volumes in the patients were compared with those of healthy controls, and were further correlated with epilepsy duration and cognitive score of executive function, respectively. By applying Granger causal analysis to the sequenced morphometric data according to disease progression information, causal network of structural covariance was constructed to assess the causal influence of structural changes from Rolandic cortices to the regions engaging executive function in the patients. Compared with healthy controls, epilepsy patients showed increased gray matter volume in the Rolandic regions, and also the regions engaging in executive function. Covariance network analyses showed that along with disease progression, the Rolandic regions imposed positive causal influence on the regions engaging in executive function. In the patients with Rolandic epilepsy, epileptogenic regions have causal influence on the structural changes in the regions of executive function, implicating damaging effects of Rolandic epilepsy on human brain. |
| Databáze: | OpenAIRE |
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