Sodium Oxybate for Alcohol Dependence: A Network Meta-Regression Analysis Considering Population Severity at Baseline and Treatment Duration

Autor: Julien Guiraud, Giovanni Addolorato, Henri-Jean Aubin, Sylvie Bachelot, Philippe Batel, Andrea de Bejczy, Amine Benyamina, Fabio Caputo, Monique Couderc, Maurice Dematteis, Anna E Goudriaan, Antoni Gual, Sylvie Lecoustey, Otto-Michael Lesch, Icro Maremmani, David J Nutt, François Paille, Pascal Perney, Jürgen Rehm, Benjamin Rolland, Bruno Scherrer, Nicolas Simon, Bo Söderpalm, Lorenzo Somaini, Wolfgang H Sommer, Rainer Spanagel, Henriette Walter, Wim van den Brink
Přispěvatelé: University of Amsterdam [Amsterdam] (UvA), Università cattolica del Sacro Cuore = Catholic University of the Sacred Heart [Roma] (Unicatt), Fondazione Policlinico Universitario A. Gemelli [Rome] (FPUAG), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Paul Brousse, D&A Pharma Paris - Laboratoires pharmaceutiques (DAPP), University of Gothenburg (GU), Università degli Studi di Ferrara = University of Ferrara (UniFE), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Université Grenoble Alpes (UGA), CHU Grenoble, Amsterdam Public Health Research Institute [The Netherlands], Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Medizinische Universität Wien = Medical University of Vienna, University of Pisa - Università di Pisa, Imperial College London, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Universitaire de Nîmes (CHU Nîmes), Centre for Addiction and Mental Health [Toronto] (CAMH), Technische Universität Dresden = Dresden University of Technology (TU Dresden), I.M. Sechenov First Moscow State Medical University [Moscow, Russia] (MSMU), Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center (CRNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Bruno Scherrer Conseil [Saint Arnoult en Yvelines] (BSC), 'Cancer, Biomedicine & Society' group (SESSTIM - U1252 INSERM - AMU - UMR 259 IRD), Sciences Economiques et Sociales de la Santé & Traitement de l'Information Médicale (SESSTIM - U1252 INSERM - Aix Marseille Univ - UMR 259 IRD), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Hôpital Sainte-Marguerite [CHU - APHM] (Hôpitaux Sud ), Addiction Treatment Center [ASL Biella, Italy] (ATC - Local Health Unit), Universität Heidelberg [Heidelberg] = Heidelberg University
Rok vydání: 2022
Předmět:
Zdroj: Alcohol and Alcoholism
Alcohol and Alcoholism, 2023, 58 (2), pp.125-133. ⟨10.1093/alcalc/agac070⟩
ISSN: 1464-3502
0735-0414
DOI: 10.1093/alcalc/agac070⟩
Popis: AimsThe estimated effect of sodium oxybate (SMO) in the treatment of alcohol dependence is heterogeneous. Population severity and treatment duration have been identified as potential effect modifiers. Population severity distinguishes heavy drinking patients with MethodsNetwork meta-regression allows for testing potential effect modifiers. It was selected to investigate the effect of the above factors on SMO efficacy defined as continuous abstinence (abstinence rate) and the percentage of days abstinent (PDA). Randomized controlled trials for alcohol dependence with at least one SMO group conducted in high-severity and mild-severity populations were assigned to a high-severity and mild-severity group of studies, respectively.ResultsEight studies (1082 patients) were retained: four in the high-severity group and four in the mild-severity group. The high-severity group was associated with larger SMO effect sizes than the mild-severity group: abstinence rate risk ratio (RR) 3.16, P = 0.004; PDA +26.9%, P ConclusionsIn the retained studies with alcohol-dependent patients, high-severity population and longer treatment duration were associated with larger SMO effect sizes.
Databáze: OpenAIRE
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