AIE-active Ir(iii ) complexes functionalised with a cationic Schiff base ligand: synthesis, photophysical properties and applications in photodynamic therapy
| Autor: | Shengnan Liu, Jiahong Han, Weijin Wang, Yulei Chang, Runlin Wang, Ziwei Wang, Guangzhe Li, Dongxia Zhu, Martin R. Bryce |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Dalton Transactions, 2022, Vol.51(42), pp.16119-16125 [Peer Reviewed Journal] |
| ISSN: | 1477-9234 1477-9226 |
| DOI: | 10.1039/d2dt02960j |
| Popis: | Photodynamic therapy (PDT) is a promising cancer treatment method. Traditional small-molecule photosensitizers (PSs) suffer from low intersystem crossing (ISC) ability and aggregation-caused quenching (ACQ), which adversely affects the luminous efficiency and singlet oxygen (1O2) yield of PSs in the aggregated state. Ir(III) complexes are promising PSs with long excited-state lifetime, good photophysical and photochemical properties and large Stokes shifts. Aggregation-induced emission (AIE) characteristics could reduce the nonradiative recombination and improve the ISC ability of excited states through the restriction of the intramolecular motions in aggregated states. Accordingly, two AIE-active Ir(III) complexes Ir-1-N+ and Ir-2-N+ were successfully designed and obtained based on Schiff base ligands. Experimental results showed that Ir-1-N+ and Ir-2-N+ have good photophysical properties and the corresponding nanoparticles (NPs) have good water solubility and 1O2 generation ability. Notably, Ir-2-N+ NPs can be efficiently taken up by mouse breast cancer cells (4T1 cells) with good biocompatibility, low dark toxicity and excellent phototoxicity. This work demonstrates a versatile strategy for exploiting efficient transition metal PSs with a cationic ligand in PDT. |
| Databáze: | OpenAIRE |
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