Heterogeneity of tyrosine hydroxylase expressing neurons in the main olfactory bulb of the mouse
| Autor: | Angela Pignatelli, Katsuko Kosaka, Toshio Kosaka |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Tyrosine 3-Monooxygenase Socio-culturale Mice Transgenic Dendrite Short-axon cell Axon Ankyrin G Axon Axon initial segment Dendrite Glomerulus Immunohistochemistry Short-axon cell Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine LS5_1 Biocytin medicine Animals Neurons Glomerulus (olfaction) Lucifer yellow Biotinylated dextran amine urogenital system General Neuroscience General Medicine Axon initial segment Olfactory Bulb Immunohistochemistry Axons Olfactory bulb Cell biology 030104 developmental biology medicine.anatomical_structure nervous system chemistry Glomerulus Ankyrin G 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Research. 157:15-33 |
| ISSN: | 0168-0102 |
| DOI: | 10.1016/j.neures.2019.10.004 |
| Popis: | The structural features of dopamine (DA)-GABAergic neurons in the mouse main olfactory bulbs were examined, using both wild type and transgenic TH-GFP mice, with the combination of several methods; the immunocytochemistry, biotinylated dextran amine labeling, lucifer yellow injection in fixed slices, biocytin injection in live slice and the functional olfactory deprivation. DA-GABAergic neurons were clustered in the glomerular layer (GL) but they also scattered in other layers. DA-GABAergic juxtaglomerular neurons, were classified into 5 groups based on their structural features and named as follows: 1) Large periglomerular (LPG) cells with tuft-like glomerular dendritic branches and apparent axons extending to the distant glomeruli, which correspond to the " inhibitory juxtaglomerular association (IJGA) neurons" participating in the interglomerular association system. 2) Small periglomerular (SPG) cells including both axonic and anaxonic ones; the axonic SPG cells might correspond to the classical periglomerular cells. 3) Transglomerular cells extending dendritic processes spanning 2 or more glomeruli. 4) Incrusting cells extending their dendritic branches mainly in the periphery of the glomeruli. 5) Other various neurons not-yet classified. In the layers other than the GL various types of TH expressing neurons were scattered; some of them extended dendritic processes into the GL. |
| Databáze: | OpenAIRE |
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