The development of cortical beta-adrenoceptor subsensitivity in the rat by chronic treatment with trazodone, doxepin and mianserine
| Autor: | S. Clements-Jewery |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Mianserin Pharmacology Piperazines β adrenoceptor Cellular and Molecular Neuroscience chemistry.chemical_compound Dibenzazepines Internal medicine Receptors Adrenergic beta medicine Animals Alprenolol Cerebral Cortex Membranes Chemistry Antagonist Trazodone Brain Doxepin Blockade Rats Receptors Adrenergic Endocrinology Dihydroalprenolol Antidepressant medicine.drug |
| Zdroj: | Neuropharmacology. 17(9) |
| ISSN: | 0028-3908 |
| Popis: | Chronic, but not acute, treatment of rats with 10mg/kg/day Trazodone, Doxepin and Mianserine decreased the specific binding of [3H] dihydroalprenolol, a potent β-adrenergic antagonist, to cortical membrane preparations, to respectively 21, 65 and 82% of the control value. Of the three antidepressant drugs, only Doxepin and Mionserine have been reported to significantly inhibit the high affinity uptake of noradrenaline, suggesting that mechanisms other than uptake blockade may contribute to the antidepressant effects of these drugs. |
| Databáze: | OpenAIRE |
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