Vitamin B supplementation and nutritional intake of methyl donors in patients with chronic kidney disease: A critical review of the impact on epigenetic machinery

Autor: Maria Cappuccilli, Floriana A Giacomelli, Diletta Conte, Teresa Natali, Camilla Bergamini, Gabriele Donati, Giuseppe Cianciolo, Irene Capelli, Gaetano La Manna
Přispěvatelé: Cappuccilli M., Bergamini C., Giacomelli F.A., Cianciolo G., Donati G., Conte D., Natali T., La Manna G., Capelli I.
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Methyltransferase
Homocysteine
Folic acid
030232 urology & nephrology
Physiology
Review
urologic and male genital diseases
vitamin B6
Choline
Epigenesis
Genetic
chemistry.chemical_compound
Eating
0302 clinical medicine
Methionine
Chronic kidney disease
Medicine
Nutritional Physiological Phenomena
cobalamin
education.field_of_study
Methyl donor
Nutrition and Dietetics
DNA methylation
Epigenetic
Vitamin B12 sublingual formulation
Cobalamin
Vitamin B 12
Cardiovascular Diseases
lcsh:Nutrition. Foods and food supply
epigenetic
Hyperhomocysteinemia
Population
lcsh:TX341-641
03 medical and health sciences
folic acid
vitamin B12 sublingual formulation
Humans
Epigenetics
Vitamin B12
Renal Insufficiency
Chronic
education
Uremia
business.industry
medicine.disease
methyl donors
Vitamin B 6
Betaine
030104 developmental biology
chemistry
Vitamin B6
Dietary Supplements
Kidney Failure
Chronic
business
chronic kidney disease
Food Science
Kidney disease
Zdroj: Nutrients
Nutrients, Vol 12, Iss 1234, p 1234 (2020)
Popis: Cardiovascular morbidity and mortality are several-fold higher in patients with advanced chronic kidney disease (CKD) and end-stage renal disease (ESRD) than in the general population. Hyperhomocysteinemia has undoubtedly a central role in such a prominent cardiovascular burden. The levels of homocysteine are regulated by methyl donors (folate, methionine, choline, betaine), and cofactors (vitamin B6, vitamin B12,). Uremia-induced hyperhomocysteinemia has as its main targets DNA methyltransferases, and this leads to an altered epigenetic control of genes regulated through methylation. In renal patients, the epigenetic landscape is strictly correlated with the uremic phenotype and dependent on dietary intake of micronutrients, inflammation, gut microbiome, inflammatory status, oxidative stress, and lifestyle habits. All these factors are key contributors in methylome maintenance and in the modulation of gene transcription through DNA hypo- or hypermethylation in CKD. This is an overview of the epigenetic changes related to DNA methylation in patients with advanced CKD and ESRD. We explored the currently available data on the molecular dysregulations resulting from altered gene expression in uremia. Special attention was paid to the efficacy of B-vitamins supplementation and dietary intake of methyl donors on homocysteine lowering and cardiovascular protection.
Databáze: OpenAIRE
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