Management of infections related to totally implantable venous-access ports: challenges and perspectives
| Autor: | Christophe Beloin, Samuel A. Lee, David Lebeaux, Jean-Marc Ghigo, Nuria Fernández-Hidalgo, Ashwini Chauhan, Benito Almirante |
|---|---|
| Přispěvatelé: | Génétique des Biofilms, Institut Pasteur [Paris] (IP), Vall d'Hebron University Hospital [Barcelona], The University of New Mexico [Albuquerque], DL was supported by a grant from the AXA Research Fund and from the French Government's Investissement d'Avenir programme (ANR-10-LABX-62-IBEID) and received a travel grant in 2009 from Schering-Plough for an international conference. NF-H and BA were supported by a grant from Ministerio de Economía y Competitividad, Instituto de Salud Carlos III and European Development Regional Fund (REIPI RD12/0015). SL was supported by a grant from the Department of Veterans Affairs and the Biomedical Research Institute of New Mexico, ANR-10-LABX-0062,IBEID,Integrative Biology of Emerging Infectious Diseases(2010), Institut Pasteur [Paris], ANR-10-LABX-0062,IBEID,Biologie Intégrative des Maladies Infectieuses Emergentes(2011) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
MESH: Catheterization
Central Venous/instrumentation medicine.medical_specialty Catheterization Central Venous MESH: Candidemia/etiology MESH: Bacteremia/etiology Bacteremia 03 medical and health sciences 0302 clinical medicine Catheters Indwelling Device removal Systemic antibiotics Quality of life Risk Factors MESH: Risk Factors Epidemiology Medicine Humans Antibiotic lock 030212 general & internal medicine MESH: Anti-Bacterial Agents/therapeutic use MESH: Device Removal Intensive care medicine Device Removal 0303 health sciences MESH: Humans 030306 microbiology business.industry Risk of infection Candidemia MESH: Catheter-Related Infections/diagnosis MESH: Candidemia/diagnosis MESH: Catheter-Related Infections/therapy [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology MESH: Bacteremia/diagnosis 3. Good health Venous access Anti-Bacterial Agents MESH: Catheters Indwelling/adverse effects MESH: Catheterization Central Venous/methods Infectious Diseases Clinical research Catheter-Related Infections MESH: Candidemia/therapy MESH: Bacteremia/therapy business MESH: Catheter-Related Infections/etiology |
| Zdroj: | The Lancet Infectious Diseases The Lancet Infectious Diseases, 2014, 14 (2), pp.146-159. ⟨10.1016/S1473-3099(13)70266-4⟩ The Lancet Infectious Diseases, New York, NY : Elsevier Science ; The Lancet Pub. Group, 2001-, 2014, 14 (2), pp.146-159. ⟨10.1016/S1473-3099(13)70266-4⟩ |
| ISSN: | 1473-3099 1474-4457 |
| DOI: | 10.1016/S1473-3099(13)70266-4⟩ |
| Popis: | International audience; Use of totally implantable venous-access ports (TIVAPs) is standard practice for patients with diseases such as solid-tumour cancers, haematological malignancies, and chronic digestive diseases. Use of TIVAPs allows long-term administration of venotoxic compounds, improves patients' quality of life, and reduces the risk of infection. Microbial contamination, formation of pathogenic biofilms, and infection, however, are associated with morbidity, mortality, and increased health-care costs. Local and systemic complications or infections related to specific pathogens might lead to device removal. Alternatively, conservative treatment with combined systemic antibiotics and antibiotic lock therapy might be useful. We discuss in-vitro and in-vivo basic and clinical research findings on the epidemiology, diagnosis, and prevention of TIVAP-related infections, the current challenges to management, promising strategies, and some treatments in development that are likely to improve outcomes of TIVAP-related infections, with a particular focus on antibiotic lock therapy. |
| Databáze: | OpenAIRE |
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