Benefits of skeletal-muscle exercise training in pulmonary arterial hypertension: The WHOLEi + 12 trial
| Autor: | Angela Flox-Camacho, Diego Munguía-Izquierdo, Carmen Fiuza-Luces, Pilar Escribano-Subías, Carlos A. Quezada-Loaiza, Alfredo Santalla, Fabian Sanchis-Gomar, Alejandro Lucia, Ignacio Ara, Paz Sanz-Ayan, Alejandro Santos-Lozano, Laura González-Saiz, María Morán |
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| Jazyk: | Spanish; Castilian |
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Weakness Adolescent Hypertension Pulmonary 030204 cardiovascular system & hematology Breathing Exercises Bench press law.invention Young Adult 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine Clinical endpoint Humans Medicine Leg press Exercise Aged Retrospective Studies Exercise Tolerance business.industry VO2 max Skeletal muscle Resistance Training Middle Aged Aparato respiratorio Respiratory Muscles medicine.anatomical_structure 030228 respiratory system Quality of Life Physical therapy Cardiology Female Analysis of variance medicine.symptom Cardiology and Cardiovascular Medicine business Hipertensión pulmonar Pulmones - Enfermedades |
| Zdroj: | ABACUS. Repositorio de Producción Científica Universidad Europea (UEM) |
| Popis: | Pulmonary arterial hypertension is often associated with skeletal-muscle weakness. The purpose of this randomized controlled trial was to determine the effects of an 8-week intervention combining muscle resistance, aerobic and inspiratory pressure-load exercises on upper/lower-body muscle power and other functional variables in patients with this disease. Participants were allocated to a control (standard care) or intervention (exercise) group (n = 20 each, 45 ± 12 and 46 ± 11 years, 60% women and 10% patients with chronic thromboembolic pulmonary hypertension per group). The intervention included five, three and six supervised (inhospital) sessions/week of aerobic, resistance and inspiratory muscle training, respectively. The primary endpoint was peak muscle power during bench/leg press; secondary outcomes included N-terminal pro-brain natriuretic peptide levels, 6-min walking distance, five-repetition sit-to-stand test, maximal inspiratory pressure, cardiopulmonary exercise testing variables (e.g., peak oxygen uptake), health-related quality of life, physical activity levels, and safety. Adherence to training sessions averaged 94 ± 0.5% (aerobic), 98 ± 0.3% (resistance) and 91 ± 1% (inspiratory training). Analysis of variance showed a significant interaction (group × time) effect for leg/bench press (P < 0.001/P = 0.002), with both tests showing an improvement in the exercise group (P < 0.001) but not in controls (P > 0.1). We found a significant interaction effect (P < 0.001) for five-repetition sit-to-stand test, maximal inspiratory pressure and peak oxygen uptake (P < 0.001), indicating a training-induced improvement. No major adverse event was noted due to exercise. An 8-week exercise intervention including aerobic, resistance and specific inspiratory muscle training is safe for patients with pulmonary arterial hypertension and yields significant improvements in muscle power and other functional variables. Sin financiación 4.034 JCR (2017) Q2, 41/128 Cardiac and Cardiovascular Systems 1.200 SJR (2017) Q1, 78/369 Cardiology and Cardiovascular Medicine No data IDR 2017 UEM |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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