Effects of halothane and enflurane on prostanoid concentrations in operation patients
| Autor: | R. Ojanen, S. Kaukinen, Erkki Seppälä, L. Kaukinen, Heikki Vapaatalo |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
Blood Platelets Male Physiology Thromboxane 6-Ketoprostaglandin F1 alpha Biochemistry Dinoprostone Enflurane chemistry.chemical_compound Endocrinology Preoperative level Humans Medicine Anesthesia In patient business.industry Prostaglandins E Prostanoid Middle Aged Thromboxane B2 Kinetics chemistry Surgical Procedures Operative Breathing Female lipids (amino acids peptides and proteins) Halothane business medicine.drug Abdominal surgery |
| Zdroj: | Prostaglandins, Leukotrienes and Medicine. 29:85-94 |
| ISSN: | 0262-1746 |
| DOI: | 10.1016/0262-1746(87)90100-4 |
| Popis: | Prostanoid formation may be stimulated by different events associated with anaesthesia and operation, such as positive pressure ventilation and tissue trauma. We investigated the effects of halothane and enflurane on plasma and serum prostanoid concentrations in 19 patients scheduled for minor operations. In 9 abdominal surgery patients, thromboxane B 2 concentrations were followed up to the fifth postoperative day. Prostanoid determinations were carried out with RIA. In general, the changes in prostanoid concentrations in patients anaesthetised with halothane or enflurane were similar. During spontaneous breathing there was a decrease in plasma PGE 2 and TxB 2 concentrations. During intermittent positive pressure ventilation and operation, PGE 2 and TxB 2 concentrations rose but 6-keto-PGF 1α did not. After operation, TxB 2 concentrations remained elevated but the other prostanoids returned to preoperative values. TxB 2 concentrations decreased to the preoperative level on the first postoperative day. The elevated TxB 2 concentrations during and after surgery can be regarded, in some patients, as a potential risk factor for cardiovascular and thromboembolic complications. |
| Databáze: | OpenAIRE |
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