Effects of bisphosphonate on oxidative stress levels in patients with different types of cancer
| Autor: | Mustafa Nazıroğlu, Tolga Taha Sönmez, Murat Koçer, Gülperi Koçer |
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| Rok vydání: | 2013 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty medicine.medical_treatment chemistry.chemical_element Calcium medicine.disease_cause Lipid peroxidation chemistry.chemical_compound Internal medicine Neoplasms medicine Humans Vitamin E In patient Aged chemistry.chemical_classification Glutathione Peroxidase Diphosphonates business.industry Glutathione peroxidase Cancer General Medicine Bisphosphonate Middle Aged medicine.disease Oxidative Stress Endocrinology Oncology chemistry Case-Control Studies Female Lipid Peroxidation business Oxidative stress |
| Zdroj: | Cancer investigation. 32(2) |
| ISSN: | 1532-4192 |
| Popis: | We investigated the effects of bisphosphonate (BP) on oxidative stress levels in blood of patients with cancer. In total, 19 patients with cancer and 21 healthy subjects were included in the study. BP was intravenously administrated to the participants for 6 weeks. The patients had higher lipid peroxidation (LP) levels in the plasma and erythrocyte samples but lower glutathione peroxidase (GSH-Px) and plasma vitamin E values. In patients treated with BP, calcium and LP levels decreased, but GSH-Px and vitamin E values improved. In conclusion, we observed that treatment with BP alleviated oxidative stress induced by cancer. |
| Databáze: | OpenAIRE |
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