Successful treatment of pyoderma gangrenosum with concomitant immunoglobulin A nephropathy: A case report and review of literature

Autor: Zhi-Gang Ma, Wen-Hui Huang, Xiaoli Li, Yunfei Hao, Er-Qing Chai
Rok vydání: 2018
Předmět:
Zdroj: World Journal of Clinical Cases
ISSN: 2307-8960
DOI: 10.12998/wjcc.v6.i13.703
Popis: Pyoderma gangrenosum (PG) is an uncommon ulcerative cutaneous condition of an unknown etiology and is often associated with immune diseases. However, PG rarely shows visceral involvement, especially in the kidney. A 20-year-old female presented with pedal edema and skin ulceration of both lower limbs. The skin lesion began as an erythematous plaque and then became a blister. She also complained of abdominal distension and a decreasing urine volume. Laboratory data showed high proteinuria, hypoalbuminemia and hyperlipidemia. Her skin and kidney were biopsied. The pathological results indicated PG and immunoglobulin A (IgA) nephropathy. The patient was finally cured with prednisolone in combination with cyclosporine A (CsA).
Databáze: OpenAIRE