Sparse genetic tracing reveals regionally specific functional organization of mammalian nociceptors
| Autor: | Tobias Raabe, Wenqin Luo, Lian Cui, William Olson, Ishmail Abdus-Saboor, Minghong Ma, Justin Burdge |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Nociception
0301 basic medicine Spatial acuity Mouse Neurite QH301-705.5 Science Biology single neuron morphology General Biochemistry Genetics and Molecular Biology Receptors G-Protein-Coupled Mice 03 medical and health sciences 0302 clinical medicine nociceptor medicine Noxious stimulus Animals Biology (General) Spinal cord slice Skin 030304 developmental biology 0303 health sciences General Immunology and Microbiology General Neuroscience Nociceptors pain fovea Anatomy General Medicine Anatomy Regional Spinal cord Trunk 030104 developmental biology medicine.anatomical_structure nervous system somatotopic organization Nociceptor Medicine Functional organization Neuroscience 030217 neurology & neurosurgery Regional differences Research Article |
| Zdroj: | eLife eLife, Vol 6 (2017) |
| DOI: | 10.1101/149641 |
| Popis: | The human distal limbs have a high spatial acuity for noxious stimuli but a low density of pain-sensing neurites. To elucidate mechanisms underlying the ‘pain fovea’, we sparsely traced non-peptidergic nociceptors across the body using a newly generatedMrgprDCreERT2mouse line. We found that mouse plantar paw skin also has a low density of MrgprD+neurites, and individual arbors in different locations are comparable in size. Surprisingly, the central arbors of plantar paw and trunk innervating nociceptors have distinct morphologies in the spinal cord. This regional difference is well correlated with a heightened signal transmission for plantar paw circuits, as revealed by both spinal cord slice recordings and behavior assays. Taken together, our results elucidate a novel somatotopic functional organization of the mammalian pain system and suggest that regional central arbor structure could facilitate the magnification of plantar paw regions to contribute to the ‘pain fovea’. |
| Databáze: | OpenAIRE |
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