The effect of tadalafil on the time to exercise-induced myocardial ischaemia in subjects with coronary artery disease
| Autor: | Simon Braat, Dean Patterson, Jeffrey T. Emmick, Thomas M. MacDonald, Margaret R. Warner, Robert A. Kloner, Mark B. Effron, Alun Bedding, Malcolm Mitchell |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Phosphodiesterase Inhibitors Vasodilator Agents Myocardial Ischemia Hemodynamics Blood Pressure Physical exercise Coronary Artery Disease Placebo Tadalafil Coronary artery disease Nitroglycerin Double-Blind Method Internal medicine medicine Humans Pharmacology (medical) cardiovascular diseases Aged Pharmacology Analysis of Variance Cross-Over Studies Exercise Tolerance business.industry Middle Aged medicine.disease Crossover study Surgery Erectile dysfunction Blood pressure Pharmacodynamics Exercise Test Cardiology Drug Therapy Combination Female business Carbolines medicine.drug |
| Zdroj: | British Journal of Clinical Pharmacology. 60:459-468 |
| ISSN: | 1365-2125 0306-5251 |
| DOI: | 10.1111/j.1365-2125.2005.02479.x |
| Popis: | Objective To investigate the effect of tadalafil on the time to exercise-induced myocardial ischaemia in subjects with coronary artery disease (CAD). Background CAD and erectile dysfunction (ED) share similar risk factors. It is important to know the cardiovascular effects of tadalafil in patients with CAD during physical exertion that is comparable with sexual activity. Methods A randomized, placebo-controlled, double-blind, two-period, crossover study comparing the effects of tadalafil 10 mg and placebo on the time to exercise treadmill test (ETT)-induced myocardial ischaemia in subjects with stable CAD (n = 23; age range: 53–75 years, all exhibited ST-segment depression >1.5 mm at screening ETT at > 5METS). Haemodynamic responses to sublingual nitroglycerin (NTG) were assessed before and after ETT. Results Compared with placebo, tadalafil did not significantly affect the time to ETT-induced ischaemia (13 min/31 s vs. 13 min/36 s, respectively). Before exercise, NTG evoked decreases in sitting systolic blood pressure (SBP) that were significantly greater when subjects received tadalafil compared with placebo, and after exercise, more subjects experienced a decrease in SBP |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text