Statins exacerbate glucose intolerance and hyperglycemia in a high sucrose fed rodent model
| Autor: | Bhumika Prajapati, Dipeeka Mandaliya, Christopher Shamir Muggalla, Naimisha Rapaka, Sweta Patel, Uday Saxena, Sriram Seshadri, Bandish Kapadia, Parimal Misra, Phanithi Prakash Babu |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Simvastatin Sucrose Atorvastatin medicine.medical_treatment lcsh:Medicine Pharmacology chemistry.chemical_compound 0302 clinical medicine Insulin lcsh:Science chemistry.chemical_classification Multidisciplinary biology Muscles Fatty Acids medicine.anatomical_structure lipids (amino acids peptides and proteins) medicine.drug Signal Transduction Muscle tissue Article 03 medical and health sciences Glucose Intolerance medicine Animals cardiovascular diseases Cholesterol business.industry lcsh:R Insulin signalling Fatty acid nutritional and metabolic diseases Feeding Behavior Diet Rats Insulin receptor Disease Models Animal 030104 developmental biology chemistry Gene Expression Regulation Pharmacodynamics Hyperglycemia biology.protein lcsh:Q Hydroxymethylglutaryl-CoA Reductase Inhibitors business 030217 neurology & neurosurgery |
| Zdroj: | Scientific Reports Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) |
| ISSN: | 2045-2322 |
| Popis: | Statins are first-line therapy drugs for cholesterol lowering. While they are highly effective at lowering cholesterol, they have propensity to induce hyperglycemia in patients. Only limited studies have been reported which studied the impact of statins on (a) whether they can worsen glucose tolerance in a high sucrose fed animal model and (b) if so, what could be the molecular mechanism. We designed studies using high sucrose fed animals to explore the above questions. The high sucrose fed animals were treated with atorvastatin and simvastatin, the two most prescribed statins. We examined the effects of statins on hyperglycemia, glucose tolerance, fatty acid accumulation and insulin signaling. We found that chronic treatment with atorvastatin made the animals hyperglycemic and glucose intolerant in comparison with diet alone. Treatment with both statins lead to fatty acid accumulation and inhibition of insulin signaling in the muscle tissue at multiple points in the pathway. |
| Databáze: | OpenAIRE |
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