In vitro effects of crude extracts of Parkia biglobosa (Mimosaceae), Stereospermum kunthianum (Bignoniaceae) and Biophytum petersianum (Oxalidaceae) on corticosteroid secretion in rat
| Autor: | J.L. Do Rego, Hubert Vaudry, V. Contesse, Kodjo Aklikokou, K.M. Kodjo, S. Titrikou, Messanvi Gbeassor |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_specialty
Biophytum medicine.drug_class Endocrinology Diabetes and Metabolism Guinea Pigs Clinical Biochemistry ved/biology.organism_classification_rank.species Biochemistry Parkia biglobosa Guinea pig Magnoliopsida chemistry.chemical_compound Endocrinology Adrenal Cortex Hormones Corticosterone Internal medicine Adrenal Glands medicine Animals Rats Wistar Molecular Biology Plants Medicinal Aldosterone Dose-Response Relationship Drug biology Traditional medicine Plant Extracts Adrenal gland ved/biology Acacia Cell Biology biology.organism_classification Stereospermum kunthianum Rats medicine.anatomical_structure chemistry Bignoniaceae Molecular Medicine Corticosteroid Rabbits |
| Zdroj: | The Journal of Steroid Biochemistry and Molecular Biology. 100:202-208 |
| ISSN: | 0960-0760 |
| Popis: | Previous studies conducted in guinea pig, rat and rabbit have revealed that crude extracts from Parkia biglobosa, Stereospermum kunthianum and Biophytum petersianum exert hypotensive and/or hypoglycemic activities. Since corticosteroids are involved in the control of arterial blood pressure and glycemia, we have investigated the possible effects of these plant extracts on rat adrenal tissue in vitro. Short-term administration of crude semi-ethanolic extracts of P. biglobosa and S. kunthianum to perifused rat adrenal tissue did not induce any significant changes in corticosteroid output. Conversely, the B. petersianum extract caused a dose-dependent increase in corticosterone and aldosterone secretion. Repeated infusions or prolonged administration of B. petersianum extract did not produce any apparent attenuation of the steroid response. Altogether, these data indicate that a semi-ethanolic extract of B. petersianum dose-dependently stimulates corticosterone and aldosterone secretion in rat without any desensitization phenomenon. |
| Databáze: | OpenAIRE |
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