Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists

Autor: Michel P. Hermans, Cristoforo Silvestri, Nicolas Flamand, Fabio Arturo Iannotti, Dominique Maiter, Audrey Loumaye, Amandine Everard, Willem M. de Vos, Rudy Pelicaen, Clara Depommier, Nathalie M. Delzenne, Jean-Paul Thissen, Patrice D. Cani, Céline Druart, Rosa Maria Vitale, Vincenzo Di Marzo
Přispěvatelé: UCL - SSS/LDRI - Louvain Drug Research Institute, UCL - (SLuc) Service d'endocrinologie et de nutrition, UCL - SSS/IREC/EDIN - Pôle d'endocrinologie, diabète et nutrition
Rok vydání: 2021
Předmět:
Male
obesity
Endogeny
0302 clinical medicine
Microbiologie
Chlorocebus aethiops
Ingestion
Receptor
lcsh:QH301-705.5
Metabolic Syndrome
0303 health sciences
biology
Chemistry
General Medicine
Metabolic syndrome
Endocannabinoid system
3. Good health
COS Cells
Monoglycerides
Mono-palmitoyl-glycerol
Female
Akkermansia muciniphila
Human
Adult
medicine.medical_specialty
endocannabinoidome
Alpha (ethology)
mono-palmitoyl-glycerols
Context (language use)
mono-palmitoyl-glycerol
Microbiology
Article
Proliferator-activated Receptor alpha (PPARα)
03 medical and health sciences
Internal medicine
medicine
Animals
Humans
PPAR alpha
Obesity
human
endocannabinoids
PPARa
VLAG
030304 developmental biology
WIMEK
Endocannabinoidome
peroxisome proliferator-activated receptor alpha (PPARα)
Akkermansia
biology.organism_classification
medicine.disease
Endocrinology
lcsh:Biology (General)
030217 neurology & neurosurgery
Endocannabinoids
Zdroj: Cells
Cells, Vol. 10, no. 1, p. 185 [1-22] (2021)
Cells, Vol 10, Iss 185, p 185 (2021)
Volume 10
Issue 1
Cells, 10(1)
Cells 10 (2021): 1–22. doi:10.3390/cells10010185
info:cnr-pdr/source/autori:Depommier C.; Vitale R.M.; Iannotti F.A.; Silvestri C.; Flamand N.; Druart C.; Everard A.; Pelicaen R.; Maiter D.; Thissen J.-P.; Loumaye A.; Hermans M.P.; Delzenne N.M.; de Vos W.M.; Marzo V.D.; Cani P.D./titolo:Beneficial effects of akkermansia muciniphila are not associated with major changes in the circulating endocannabinoidome but linked to higher mono-palmitoyl-glycerol levels as new ppar? agonists/doi:10.3390%2Fcells10010185/rivista:Cells/anno:2021/pagina_da:1/pagina_a:22/intervallo_pagine:1–22/volume:10
Cells 10 (2021) 1
ISSN: 2073-4409
Popis: Akkermansia muciniphila is considered as one of the next-generation beneficial bacteria in the context of obesity and associated metabolic disorders. Although a first proof-of-concept of its beneficial effects has been established in the context of metabolic syndrome in humans, mechanisms are not yet fully understood. This study aimed at deciphering whether the bacterium exerts its beneficial properties through the modulation of the endocannabinoidome (eCBome). Circulating levels of 25 endogenous endocannabinoid-related lipids were quantified by liquid chromatography with tandem mass spectrometry (LC-MS/MS) in the plasma of overweight or obese individuals before and after a 3 months intervention consisting of the daily ingestion of either alive or pasteurized A. muciniphila. Results from multivariate analyses suggested that the beneficial effects of A. muciniphila were not linked to an overall modification of the eCBome. However, subsequent univariate analysis showed that the decrease in 1-Palmitoyl-glycerol (1-PG) and 2-Palmitoyl-glycerol (2-PG), two eCBome lipids, observed in the placebo group was significantly counteracted by the alive bacterium, and to a lower extent by the pasteurized form. We also discovered that 1- and 2-PG are endogenous activators of peroxisome proliferator-activated receptor alpha (PPAR&alpha
). We hypothesize that PPAR&alpha
activation by mono-palmitoyl-glycerols may underlie part of the beneficial metabolic effects induced by A. muciniphila in human metabolic syndrome.
Databáze: OpenAIRE
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