Levorotatory form of 5-hydroxytryptophan in Friedreich's ataxia. Results of a double-blind drug-placebo cooperative study
| Autor: | Claude F. Degos, Patrice Adeleine, André Rascol, Dominique Laplane, Claude Desnuelle, Daniel Michel, Georges Serratrice, Paul Augustin, Gérard Barroche, Paul Trouillas, Jean M. Warter, Michel Clanet, François Viallet, Raymond Dumas |
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| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Ataxia Adolescent medicine.medical_treatment Posture Placebo Levorotatory law.invention Central nervous system disease 5-Hydroxytryptophan Placebos Degenerative disease Arts and Humanities (miscellaneous) Randomized controlled trial Double-Blind Method law Internal medicine medicine Humans Speech Chemotherapy business.industry medicine.disease Clinical trial Friedreich Ataxia Physical therapy Female Neurology (clinical) medicine.symptom business Psychomotor Performance |
| Zdroj: | Archives of neurology. 52(5) |
| ISSN: | 0003-9942 |
| Popis: | Objective: To study the effect of the levorotatory form of 5-hydroxytryptophan on the cerebellar symptoms of Friedreich's ataxia. Design: Cooperative double-blind study of the levorotatory form of 5-hydroxytryptophan vs placebo. Setting: Twelve centers in research hospitals. Patients: Twenty-six patients were included; 19 completed the study (mean±SD age of patients, 25.9±8.1 years). Of these 19 patients, eight were treated with placebo and 11 were treated with the drug. Main Outcome Measures: A semiquantitative scale for kinetic and static ("postural") cerebellar functions and quantitative measurements of time in standard tests that evaluated stance, speech, writing, and drawing. Results: In the active treatment group, a significant decrease of the kinetic score was observed (P=.03), indicating an improvement in coordination. Conclusions: These results demonstrated that the levorotatory form of 5-hydroxytryptophan is able to modify significantly the cerebellar symptoms in patients with Friedreich's ataxia. However, the effect is only partial and not clinically major. |
| Databáze: | OpenAIRE |
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