Household organophosphorus pesticide use and parkinson's disease
| Autor: | Ritz Beate, Liew Zeyan, Sinsheimer Janet S., Narayan Shilpa, Bronstein Jeff M., Lee Pei-Chen, Paul Kimberly |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Rural Population Secondary Aging Parkinson's disease Epidemiology Rural Health Neurodegenerative Logistic regression California Non-communicable Disease Risk Factors Toxicology Pesticide use Risk Factors 80 and over Odds Ratio General Environmental Science Aged 80 and over chemistry.chemical_classification education.field_of_study organophosphorus pesticides Statistics Household Products Parkinson Disease General Medicine Middle Aged Neurological Public Health and Health Services Female Organophosphorus pesticides Adult Population Odds Organophosphorus Compounds Environmental health medicine Humans Climate-Related Exposures and Conditions Genetic Predisposition to Disease Parkinson Disease Secondary Pesticides education Aged Organothiophosphate Aryldialkylphosphatase business.industry Environmental exposures Organothiophosphates Neurosciences Environmental Exposure Odds ratio Pesticide medicine.disease United States paraoxonase Confidence interval Brain Disorders Logistic Models household pesticide use chemistry Case-Control Studies Parkinson’s disease General Earth and Planetary Sciences business |
| Zdroj: | Narayan, S; Liew, Z; Paul, K; Lee, PC; Sinsheimer, JS; Bronstein, JM; et al.(2013). Household organophosphorus pesticide use and parkinson's disease. International Journal of Epidemiology, 42(5), 1476-1485. doi: 10.1093/ije/dyt170. UCLA: Retrieved from: http://www.escholarship.org/uc/item/2t1442gr International journal of epidemiology, vol 42, iss 5 Web of Science |
| DOI: | 10.1093/ije/dyt170. |
| Popis: | Background Household pesticide use is widespread in the USA. Since the 1970s, organophosphorus chemicals (OPs) have been common active ingredients in these products. Parkinson's disease (PD) has been linked to pesticide exposures but little is known about the contributions of chronic exposures to household pesticides. Here we investigate whether long-term use of household pesticides, especially those containing OPs, increases the odds of PD. Methods In a population-based case-control study, we assessed frequency of household pesticide use for 357 cases and 807 controls, relying on the California Department of Pesticide Regulation product label database to identify ingredients in reported household pesticide products and the Pesticide Action Network pesticide database of chemical ingredients. Using logistic regression we estimated the effects of household pesticide use. Results Frequent use of any household pesticide increased the odds of PD by 47% [odds ratio (OR)=1.47, (95% confidence interval (CI): 1.13, 1.92)]; frequent use of products containing OPs increased the odds of PD more strongly by 71% [OR=1.71, (95% CI: 1.21, 2.41)] and frequent organothiophosphate use almost doubled the odds of PD. Sensitivity analyses showed that estimated effects were independent of other pesticide exposures (ambient and occupational) and the largest odds ratios were estimated for frequent OP users who were carriers of the 192QQ paraoxonase genetic variant related to slower detoxification of OPs. Conclusions We provide evidence that household use of OP pesticides is associated with an increased risk of developing PD. © The Author 2013; all rights reserved. |
| Databáze: | OpenAIRE |
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