Association of antiphospholipid antibodies with retinalvascular disease in systemic lupus erythematosus
| Autor: | Marisa Jorfán, Ricard Cervera, José Luis Callejas, Maria C. Griñó, Miguel Ingelmo, Manel Ramos-Casals, Josep Font, M García-Carrasco, Alfredo Montehermoso, Francesc Formiga |
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| Rok vydání: | 1999 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Anti-nuclear antibody Fundus Oculi Visual Acuity Enzyme-Linked Immunosorbent Assay Gastroenterology chemistry.chemical_compound Retinal Diseases Rheumatology immune system diseases Internal medicine Prevalence medicine Humans Lupus Erythematosus Systemic Prospective Studies skin and connective tissue diseases Aged Aged 80 and over Retinal Vascular Occlusion Lupus anticoagulant Lupus erythematosus Vascular disease business.industry Retinal Vessels Retinal Middle Aged Ischemic optic neuropathy medicine.disease Anesthesiology and Pain Medicine chemistry Antibodies Anticardiolipin Antibodies Antinuclear Lupus Coagulation Inhibitor Female business Retinopathy |
| Zdroj: | Seminars in Arthritis and Rheumatism. 28:326-332 |
| ISSN: | 0049-0172 |
| DOI: | 10.1016/s0049-0172(99)80017-1 |
| Popis: | Objectives: To study the prevalence and characteristics of retinal vasculardisease in patients with systemic lupus erythematosus (SLE) and to analyze their relationship with antiphospholipid antibodies (aft) and other serological markers. Patients and Methods: Eighty-two consecutive patients (77 women and 5 men; mean age, 36 years) were studied. All patients fulfilled the 1982 revised criteria of the American College of Rheumatology for the classification of SLE. Ophthalmologic examination included assessment of best corrected visual acuity, tonometry, slit-lamp biomicroscopy, and fundus examination. Serologic studies included determination of anticardiolipin antibodies (aCL) (ELISA), lupus anticoagulant (LA) (coagulation tests), antinuclear antibodies (indirect immunofluorescence), anti-DNA (Farr's test), and anti-ENA antibodies (counterimmunoelectrophoresis). Results: Retinal vascular disease was detected in 13 (15%) of 82 SLE patients. The retinal lesions consisted of retinal vascular occlusions in six patients (five arterial and one venous), cotton-wool spots in three, optic disc edema in three, retinal hemorrhages in three, and ischemic optic neuropathy in one. Antiphospholipid antibodies were detected in 10 (77%) of these 13 patients: nine had aCL and two had the LA. When compared with patients without retinal vascular disease, patients with retinopathy had a higher prevalence of aft (77% v 29%, P = .005). Conclusions: Retinal vascular disease is frequent in patients with SLE. Thepresence of aPL is associated with a higher prevalence of retinal abnormalities in SLE patients. |
| Databáze: | OpenAIRE |
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