| Autor: |
Minoru Yasukawa, Shigeyuki Arai, Michito Nagura, Ryo Kido, Shinichiro Asakawa, Daigoro Hirohama, Osamu Yamazaki, Yoshifuru Tamura, Michitaka Fujimaki, Sawako Kobayashi, Masakazu Mimaki, Hiroko Kodama, Shunya Uchida, Yoshihide Fujigaki, Shigeru Shibata |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Kidney International Reports. 7:1565-1574 |
| ISSN: |
2468-0249 |
| Popis: |
Impaired response to erythropoiesis-stimulating agents (ESAs) is associated with increased mortality in patients with end-stage kidney disease. However, the underlying mechanisms are not fully elucidated. Accumulating data reveal that selenium (Se), a trace element, plays a key role in stress erythropoiesis and erythrocyte homeostasis. We evaluated the relationship between serum Se levels and the response to ESAs in hemodialysis patients.In this cross-sectional study, we determined serum Se levels in 173 hemodialysis patients. We analyzed the association of serum Se with ESA responsiveness, as defined by ESA resistance index.Of the study participants, 50% had lower Se levels than the population-based reference values. We found that serum Se levels were significantly and inversely correlated with erythropoiesis resistance index (ERI) but not transferrin saturation (TSAT) or ferritin levels. Multiple regression analyses confirmed the association between Se levels and ESA hyporesponsiveness, independently of other known factors, such as iron status, being female, and dialysis vintage (β = -0.11,Serum Se levels are associated with the response to ESAs and can predict ESA resistance independently of iron status in Japanese hemodialysis patients. These data open the possibility to test whether Se supplementation reduces ESA demand. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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