Adverse maternal and neonatal outcome of prolonged course of magnesium sulfate tocolysis
| Autor: | Anwar H. Nassar, Khaled Sakhel, Hoda Maarouf, Ihab M. Usta, Georges Naassan |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Tocolytic agent Tocolysis chemistry.chemical_element Gestational Age Magnesium Sulfate Obstetric Labor Premature Bone Density Pregnancy Infant Mortality medicine Humans Magnesium Retrospective Studies business.industry Infant Newborn Pregnancy Outcome Case-control study Obstetrics and Gynecology Gestational age Retrospective cohort study General Medicine medicine.disease Parity Tocolytic Agents chemistry Case-Control Studies Tocolytic Anesthesia Gestation Calcium Female business |
| Zdroj: | Acta Obstetricia et Gynecologica Scandinavica. 85:1099-1103 |
| ISSN: | 1600-0412 0001-6349 |
| DOI: | 10.1080/00016340600756896 |
| Popis: | Magnesium sulfate continues to be widely used as a tocolytic agent despite a paucity of evidence supporting its use. Many practitioners use prolonged courses of magnesium sulfate, sometimes for months. This study was conducted to determine maternal and neonatal outcome of patients exposed to prolonged tocolytic magnesium sulfate.A retrospective review of maternal and neonatal charts (1995-2003) of pregnancies that received tocolytic magnesium sulfate. Cases who received magnesium sulfate48 h (n=78) were compared to controls who received itor =48 h (n=77) for maternal side effects and neonatal outcome.Cases were more likely to be nulliparous (55.1% versus 37.7%, p=0.044), multiple gestations (33.3% versus 10.4%, p=0.001), and of lower gestational age (29.0+/-3.9 versus 30.5+/-3.8 weeks, p=0.017) compared to controls. The median magnesium sulfate infused was 154 (78-5,500) versus 54 (8-86) g (p0.001) and the highest maternal magnesium level was 6.5+/-1.7 versus 5.6+/-1.9 mg/dl (p=0.002) in cases and controls, respectively. Cases were more likely to haveor =1 adverse side effect (30.8% versus 15.6%, p=0.045). The median neonatal magnesium level was significantly higher in cases (3.3 (1.4-7.2) versus 2.6 (1.1-5.2) mg/dl, p=0.016); however, neonatal mortality and other neonatal morbidity rates were similar in both groups. Abnormal bone mineralization was encountered in 3 neonates (cases).Maternal morbidity rate is higher with prolonged intake of tocolytic magnesium sulfate compared toor =48-h regimen. Despite similar neonatal morbidity and mortality rates, bone demineralization in the neonates may be encountered. |
| Databáze: | OpenAIRE |
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