A 22 years survival and prognostic factors analysis in a homogeneous series of 64 patients with advanced cancer of the tongue and the floor of the mouth
| Autor: | Jose L. López-Cedrún, Jesús Andrés de Llano |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Capsular Invasion medicine.medical_specialty medicine.medical_treatment Comorbidity Gastroenterology Disease-Free Survival Tongue Cause of Death Internal medicine Carcinoma Humans Medicine Neoplasm Invasiveness Stage (cooking) Mouth Floor Aged Neoplasm Staging Retrospective Studies Salvage Therapy Series (stratigraphy) business.industry Proportional hazards model Age Factors Middle Aged Prognosis medicine.disease Primary tumor Neoadjuvant Therapy Tongue Neoplasms Surgery Survival Rate Radiation therapy medicine.anatomical_structure Otorhinolaryngology Lymphatic Metastasis Carcinoma Squamous Cell Female Mouth Neoplasms Neoplasm Grading Neoplasm Recurrence Local Oral Surgery business Follow-Up Studies |
| Zdroj: | Journal of Cranio-Maxillofacial Surgery. 43:376-381 |
| ISSN: | 1010-5182 |
| Popis: | Purpose The aim of this study is to evaluate patients with advanced tongue and floor of the mouth carcinoma evaluating clinical and histopathologic parameters as prognostic factors for survival. Methods We studied retrospectively 64 patients with squamous cell carcinomas of the tongue and floor of the mouth in stage III and IV, treated by surgery at first and followed them for at least 22 years or until death, with a median follow-up of 67 months (range, 3–290 months). The prognosis factors evaluation included tumor, patient and treatment related factors using univariate and multivariate statistical analysis. Results The overall 5-year and 22-year survival rates were 34.4% and 6.3%, respectively; and the specific 5-year and 22 years survival rates 35.9%. Eleven patients (17.2%) had died of a second primary tumor and 8 (12.5%) of intercurrent diseases. Multivariable Cox regression analysis showed node capsular invasion, number of metastatic nodes and malignancy grading as the main factors associated with survival (p Conclusion A very long-term follow-up allowed for the observation of the specific and the overall survival, influenced by age and comorbidities. The prognosis was strongly influenced by the ganglionar status and the histopathological characteristics of the primary tumor. |
| Databáze: | OpenAIRE |
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