Anti-Glycemic and Anti-Hepatotoxic Effects of Mangosteen Vinegar Rind from Garcinia mangostana Against HFD/STZ-Induced Type II Diabetes in Mice
Autor: | Nutjaree Jeenduang, Jitbanjong Tangpong, Naymul Karim |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
hepatotoxicity medicine.medical_specialty food.ingredient MVR lcsh:TX341-641 oxidative damage Superoxide dismutase Glibenclamide 03 medical and health sciences chemistry.chemical_compound food Internal medicine medicine Nutrition and Dietetics diabetes 030102 biochemistry & molecular biology Glycogen biology Increased hepatic glycogen content Malondialdehyde Streptozotocin high-fat diet 030104 developmental biology Endocrinology chemistry biology.protein Garcinia mangostana Trolox lcsh:Nutrition. Foods and food supply Food Science medicine.drug |
Zdroj: | Polish Journal of Food and Nutrition Sciences, Vol 68, Iss 2, Pp 163-169 (2018) |
ISSN: | 1230-0322 |
DOI: | 10.1515/pjfns-2017-0018 |
Popis: | This study focuses on anti-glycemic and anti-hepatotoxic effects of mangosteen vinegar rind (MVR) on five weeks high-fat diet (HFD) / single dose streptozotocin (STZ) 30 mg/kg BW induced male ICR diabetic mice. Mice were randomly divided into five groups (n=6), normal control, diabetic control, and diabetic groups treated with MVR 100, 200 mg/kg BW and glibenclamide 60 mg/kg BW for one week. After the treatment, lipid profile, glycogen and bilirubin contents, oxidative damage (malondialdehyde, MDA), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) activities, antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) were measured in plasma and/or liver tissues. MVR and glibenclamide treatment to HFD/STZ-induced diabetic mice significantly reduced their plasma glucose, plasma lipid profile, and hepatic lipid profile (P |
Databáze: | OpenAIRE |
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