Infantile intestinal leiomyosarcoma is prognostically favorable despite histologic aggressiveness: Case report and literature review
| Autor: | Yoshiyuki Kisaki, Hideki Yamamoto, Hitoshi Ikeda, Junko Fujino, Hiroo Uchida, Yoshiomi Mori, Takayoshi Tsuchiya, Yuki Ishimaru, Morikazu Yoshida |
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| Rok vydání: | 2004 |
| Předmět: |
Leiomyosarcoma
Pathology medicine.medical_specialty medicine.medical_treatment CD34 Colonic Polyps Melena Submucosa Laparotomy Biomarkers Tumor Mitotic Index Adjuvant therapy Humans Medicine Neoplasm Invasiveness Stromal tumor biology GiST business.industry CD117 Infant General Medicine Prognosis medicine.disease Actins digestive system diseases Neoplasm Proteins medicine.anatomical_structure Phosphopyruvate Hydratase Colonic Neoplasms Pediatrics Perinatology and Child Health biology.protein Female Surgery Tomography X-Ray Computed business Intussusception |
| Zdroj: | Journal of Pediatric Surgery. 39:1257-1260 |
| ISSN: | 0022-3468 |
| DOI: | 10.1016/j.jpedsurg.2004.04.021 |
| Popis: | Intestinal leiomyosarcomas in children are extremely rare. The authors present a case of infantile intestinal leiomyosarcoma of the colon that was resected and was classified histologically as grade 2 because of abundant mitoses. The tumor cells infiltrated the submucosa and the serosal surface. Immunohistochemically, these cells were positive for alpha-smooth muscle actin but not for CD34 or CD117, by which the tumor was differentiated from gastrointestinal stromal tumor (GIST). The patient underwent follow-up without adjuvant therapy and is now doing well with no evidence of the disease for 42 months. Based on the current case and a review of 18 reported cases, it is concluded that infantile intestinal leiomyosarcoma, which is differentiated from GIST, has a favorable prognosis even when the histologic appearance is suggestive of aggressive biological characteristics. Adjuvant therapy is unnecessary when tumors are completely resected. |
| Databáze: | OpenAIRE |
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