Higher Levels of a Cytotoxic Protein, Vaginolysin, in Lactobacillus-Deficient Community State Types at the Vaginal Mucosa

Autor:	Jacques Ravel, Xin He, Elbert D. Glover, Rebecca M. Brotman, Purnahamsi Desai, Adam J. Ratner, Jessica M Rath, Rebecca G. Nowak, Tara M. Randis, Courtney K. Robinson
Rok vydání:	2018
Předmět:	Adult 0301 basic medicine Microbiology (medical) Vaginal Douching Adolescent Bacterial Toxins 030106 microbiology Dermatology medicine.disease_cause Article Microbiology Young Adult 03 medical and health sciences Bacterial Proteins Lactobacillus medicine Humans Cytotoxic T cell Gardnerella vaginalis Mucous Membrane biology business.industry Vaginal mucosa Public Health Environmental and Occupational Health Vaginosis Bacterial Hydrogen-Ion Concentration Middle Aged biology.organism_classification medicine.disease female genital diseases and pregnancy complications Vaginal ph 030104 developmental biology Infectious Diseases Vagina Female Bacterial vaginosis business
Zdroj:	Sexually Transmitted Diseases. 45:e14-e17
ISSN:	1537-4521 0148-5717
DOI:	10.1097/olq.0000000000000774
Popis:	Vaginolysin (VLY), a cytotoxic protein produced by Gardnerella vaginalis, may contribute to bacterial vaginosis. We observed that women with G. vaginalis, low levels of lactobacilli, history of vaginal douching, higher Nugent scores, and higher vaginal pH had increased VLY. Inflammatory markers were not highly expressed with increasing VLY. Vaginolysin's role in bacterial vaginosis warrants further evaluation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1fc9fb84e8b3b73a144ec900cbeab26 https://doi.org/10.1097/olq.0000000000000774 Zobrazit plný text záznamu